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Mtnr1a melatonin receptor 1A [ Mus musculus (house mouse) ]

Gene ID: 17773, updated on 21-Apr-2024

Summary

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Official Symbol
Mtnr1aprovided by MGI
Official Full Name
melatonin receptor 1Aprovided by MGI
Primary source
MGI:MGI:102967
See related
Ensembl:ENSMUSG00000054764 AllianceGenome:MGI:102967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MR; MelR
Summary
Predicted to enable hormone binding activity; melatonin receptor activity; and organic cyclic compound binding activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of insulin secretion. Predicted to act upstream of or within signal transduction. Predicted to be located in neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; gonad; intestine; and liver and biliary system. Orthologous to human MTNR1A (melatonin receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.3), liver adult (RPKM 0.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B1.1; 8 24.95 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45522144..45542270)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45069107..45089233)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21352 Neighboring gene STARR-seq mESC enhancer starr_21353 Neighboring gene predicted gene 9908 Neighboring gene STARR-seq mESC enhancer starr_21356 Neighboring gene STARR-seq mESC enhancer starr_21359 Neighboring gene FAT atypical cadherin 1 Neighboring gene STARR-seq mESC enhancer starr_21360 Neighboring gene STARR-seq mESC enhancer starr_21361 Neighboring gene STARR-seq mESC enhancer starr_21364 Neighboring gene cDNA sequence AY512931 Neighboring gene STARR-seq mESC enhancer starr_21366 Neighboring gene predicted gene, 30504 Neighboring gene STARR-seq mESC enhancer starr_21368 Neighboring gene predicted gene 6329 Neighboring gene STARR-seq mESC enhancer starr_21369 Neighboring gene coagulation factor XI

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function. Talpur HS, et al. Reprod Biol, 2017 Dec. PMID 29097083
  2. Melatonin Receptor 1 Deficiency Affects Feeding Dynamics and Pro-Opiomelanocortin Expression in the Arcuate Nucleus and Pituitary of Mice. Fischer C, et al. Neuroendocrinology, 2017. PMID 27490331
  3. Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling. Gianesini C, et al. Invest Ophthalmol Vis Sci, 2016 Jan 1. PMID 26780313, Free PMC Article
  4. Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice. Comai S, et al. Int J Neuropsychopharmacol, 2015 Jan 31. PMID 25638817, Free PMC Article
  5. Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice. Adamah-Biassi EB, et al. Horm Behav, 2014 Sep. PMID 25200199, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
    Title: The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
  2. Changes in melatonin receptor expression in a murine model of glaucoma.
    Title: Changes in melatonin receptor expression in a murine model of glaucoma.
  3. found in The organ of Corti, spiral ganglion, vestibular ganglion, vestibular sensory cells, vestibular dark and transitional cells, and endolymphatic sac epithelial cells
    Title: Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.
  4. MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
    Title: MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.
  5. study presents the first direct evidence that the MT2 subtype, but not MT1, is a novel endogenous cardiac protective receptor against MI/R injury. Medications specifically targeting MT2 may hold promise in fighting ischemic heart disease.
    Title: Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.
  6. MT1/MT2 receptors activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
    Title: Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway.
  7. These results suggested that the melatonin receptors MTNR1A and MTNR1B are essential to repress hCG-induced endoplasmic reticulum stress and cell apoptosis.
    Title: Melatonin receptor depletion suppressed hCG-induced testosterone expression in mouse Leydig cells.
  8. Melatonin MT1 and MT2 receptors interact with dopamine transporter (DAT) in striatum.
    Title: Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.
  9. our data demonstrate that the activation of MT1 signaling at night modulates insulin sensitivity during the day via the regulation of the PI3K transcription and activity
    Title: Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.
  10. knockdown of melatonin receptor leads to interference in the normal physiological function of the ovary by enhancing follicular apoptosis, inhibiting proliferation, and influencing hormonal signaling
    Title: Knockdown of melatonin receptor 1 and induction of follicle-stimulating hormone on the regulation of mouse granulosa cell function.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC151277

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables melatonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables melatonin receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within circadian rhythm TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
melatonin receptor type 1A
Names
Mel1a receptor
mel-1A-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008639.3 → NP_032665.1  melatonin receptor type 1A

    See identical proteins and their annotated locations for NP_032665.1

    Status: VALIDATED

    Source sequence(s)
    AC158352
    Consensus CDS
    CCDS22273.1
    UniProtKB/Swiss-Prot
    Q61184
    UniProtKB/TrEMBL
    Q14AC3
    Related
    ENSMUSP00000069872.8, ENSMUST00000067984.9
    Conserved Domains (2) summary
    pfam00001
    Location:47 → 298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:38 → 160
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    45522144..45542270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509292.2 → XP_006509355.2  melatonin receptor type 1A isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:31 → 56
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:27 → 275
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_017312597.1 → XP_017168086.1  melatonin receptor type 1A isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:30 → 55
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:26 → 274
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_011242176.1 → XP_011240478.1  melatonin receptor type 1A isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:3 → 28
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:3 → 247
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_006509291.3 → XP_006509354.1  melatonin receptor type 1A isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:3 → 28
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:3 → 247
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61184.1 GenPept UniProtKB/Swiss-Prot:Q61184

Gene LinkOut

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