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egl-21 Carboxypeptidase E [ Caenorhabditis elegans ]

Gene ID: 177940, updated on 4-Jan-2025

Summary

Official Symbol
egl-21
Official Full Name
Carboxypeptidase E
Primary source
WormBase:WBGene00001189
Locus tag
CELE_F01D4.4
See related
AllianceGenome:WB:WBGene00001189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables carboxypeptidase activity. Involved in several processes, including acetylcholine secretion, neurotransmission; cellular response to carbon dioxide; and positive regulation of secretion. Located in axon; cytoplasmic vesicle; and neuronal cell body. Is expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in alcohol dependence; carboxypeptidase N deficiency; coronary artery disease; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including CPE (carboxypeptidase E). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See egl-21 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (10478442..10481844, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene glucuronosyltransferase Neighboring gene I-beta-1,3-N-acetylglucosaminyltransferase Neighboring gene pseudo Neighboring gene PHD-type domain-containing protein Neighboring gene Dedicator of cytokinesis protein 1 Neighboring gene Serine/threonine-protein phosphatase 2B catalytic subunit

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity  
enables carboxypeptidase activity PubMed 
enables metal ion binding  
enables metallocarboxypeptidase activity  
enables metallocarboxypeptidase activity  
enables metallopeptidase activity  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in acetylcholine secretion, neurotransmission PubMed 
involved_in cellular response to carbon dioxide PubMed 
involved_in larval feeding behavior PubMed 
involved_in negative regulation of nematode pharyngeal pumping PubMed 
involved_in neuropeptide processing PubMed 
involved_in peptide metabolic process  
involved_in positive regulation of acetylcholine secretion, neurotransmission PubMed 
involved_in positive regulation of acetylcholine secretion, neurotransmission PubMed 
involved_in positive regulation of defecation PubMed 
involved_in positive regulation of defecation PubMed 
involved_in positive regulation of digestive system process PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior PubMed 
involved_in positive regulation of synaptic assembly at neuromuscular junction PubMed 
involved_in protein processing  
involved_in protein processing PubMed 
involved_in proteolysis  
involved_in regulation of eating behavior PubMed 
involved_in regulation of muscle contraction PubMed 
involved_in regulation of muscle contraction PubMed 
Component Evidence Code Pubs
located_in axon PubMed 
located_in axon  
located_in cell projection  
located_in cytoplasmic vesicle PubMed 
located_in cytoplasmic vesicle  
is_active_in extracellular space  
located_in neuronal cell body PubMed 
located_in perikaryon  
located_in presynapse  

General protein information

Preferred Names
Carboxypeptidase E
NP_501935.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10478442..10481844 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069534.7NP_501935.1  Carboxypeptidase E [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501935.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17754
    Conserved Domains (2) summary
    cd03858
    Location:40358
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
    cd11308
    Location:362446
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
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