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DNM2 dynamin 2 [ Homo sapiens (human) ]

Gene ID: 1785, updated on 4-Jan-2025

Summary

Official Symbol
DNM2provided by HGNC
Official Full Name
dynamin 2provided by HGNC
Primary source
HGNC:HGNC:2974
See related
Ensembl:ENSG00000079805 MIM:602378; AllianceGenome:HGNC:2974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DYN2; CMT2M; DYNII; LCCS5; CMTDI1; CMTDIB; DI-CMTB
Summary
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in colon (RPKM 49.5), stomach (RPKM 41.1) and 25 other tissues See more
Orthologs
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Genomic context

See DNM2 in Genome Data Viewer
Location:
19p13.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10718079..10831903)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10844675..10958914)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10828755..10942579)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10087 Neighboring gene interleukin enhancer binding factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10801737-10802532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10802533-10803326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10806023-10806522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10811832-10812580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13985 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:10826293-10826482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13986 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13988 Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13989 Neighboring gene microRNA 638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10859277-10860091 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:10861227-10861848 Neighboring gene uncharacterized LOC124904637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13993 Neighboring gene microRNA 4748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10922359-10923291 Neighboring gene microRNA 199a-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:10945386-10946023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10946661-10947297 Neighboring gene microRNA 6793 Neighboring gene chromosome 19 open reading frame 38 Neighboring gene HIKESHI pseudogene 2 Neighboring gene transmembrane p24 trafficking protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

EBI GWAS Catalog

Description
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication requires DNM2 expression; knockdown through shRNA expression decreased viral replication in monocyte derived dendritic cell and CD4+ T cell mixed cultures PubMed
Knockdown of dynamin 2 (DNM2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of dynamin 2 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Envelope transmembrane glycoprotein gp41 env The cytoplasmic tail, in particular amino acids 718-723, of HIV-1 gp41 is an important determinant for dynasore (a dynamin inhibitor) sensitivity in HIV-mediated cell-cell fusion PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nef Dyn2 is required for the infectivity enhancement function of Nef. The K44A mutant of Dyn2 markedly reduces the infectivity of nef-positive HIV PubMed
nef Nef specifically interacts with dynamin 2 (Dyn2) in an in vitro pull-down assay. The middle domain and the GED of Dyn2 are both necessary and together confer full Nef binding while the myristyl moiety of Nef is critical for the interaction with Dyn2 PubMed
nef HIV-1 Nef enhances the infectivity of CD4-chemokine receptor-pseudotyped HIV-1 for target cells expressing HIV-1 Env. Virus-producing cells expressing dominant-negative dynamin 2 (K44A) selectively inhibits these receptor-pseudotyped virions PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify dynamin 2 (DNM2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
gag Dynamin-dependent endocytosis is required for intracellular accumulation of HIV-1 Gag in the presence of HLA-DR PubMed
gag HIV-1 Gag co-localizes with dynamin in primary T lymphocytes PubMed
Vpu vpu Dominant negative dynamin 2 (K44A) acts as an inhibitor of clathrin-mediated endocytosis and inhibits the downregulation of BST-2 from the cell surface by HIV-1 Vpu PubMed
capsid gag Dynamin 2 depletion by shRNA results in inhibition of the HIV-1 CA uptake by target cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding PubMed 
enables GTPase activity  
enables GTPase activity PubMed 
enables GTPase activity PubMed 
enables GTPase activity  
enables SH3 domain binding PubMed 
enables enzyme binding PubMed 
enables membrane scission GTPase motor activity  
enables microtubule binding  
enables microtubule binding PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding PubMed 
enables protein binding PubMed 
Items 1 - 25 of 31
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle PubMed 
involved_in actin filament bundle organization PubMed 
involved_in actin filament bundle organization  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II  
involved_in autophagy PubMed 
involved_in autophagy PubMed 
involved_in centrosome cycle  
involved_in endocytosis PubMed 
involved_in endocytosis PubMed 
involved_in membrane organization  
involved_in membrane tubulation PubMed 
involved_in membrane tubulation  
involved_in negative regulation of membrane tubulation PubMed 
involved_in neuron projection morphogenesis  
involved_in phagocytosis  
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of apoptotic process PubMed 
involved_in post-Golgi vesicle-mediated transport  
involved_in protein polymerization PubMed 
involved_in receptor internalization  
involved_in receptor internalization PubMed 
involved_in receptor-mediated endocytosis PubMed 
involved_in receptor-mediated endocytosis  
involved_in regulation of DNA-templated transcription PubMed 
involved_in regulation of axon extension  
involved_in signal transduction PubMed 
involved_in stress fiber assembly  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane  
involved_in synaptic vesicle transport PubMed 
involved_in transferrin transport PubMed 
involved_in vesicle scission PubMed 
Items 1 - 25 of 31
Items 1 - 20 of 29
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi membrane  
located_in centriole PubMed 
located_in centrosome PubMed 
located_in clathrin-coated pit  
located_in clathrin-coated vesicle PubMed 
is_active_in cytoplasm  
located_in cytosol PubMed 
located_in cytosol  
located_in endocytic vesicle membrane  
located_in endosome PubMed 
located_in extracellular exosome PubMed 
located_in focal adhesion PubMed 
colocalizes_with growth cone  
is_active_in microtubule  
located_in microtubule PubMed 
located_in midbody  
located_in neuron projection  
located_in phagocytic cup  
located_in phagocytic vesicle membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in podosome  
located_in postsynaptic density  
located_in postsynaptic membrane PubMed 
located_in presynapse  
located_in recycling endosome PubMed 
is_active_in synapse  
located_in uropod PubMed 
Items 1 - 20 of 29

General protein information

Preferred Names
dynamin-2
Names
dynamin II
NP_001005360.1
NP_001005361.1
NP_001005362.1
NP_001177645.1
NP_004936.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008792.1 RefSeqGene

    Range
    4975..118832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_238

mRNA and Protein(s)

  1. NM_001005360.3NP_001005360.1  dynamin-2 isoform 1

    See identical proteins and their annotated locations for NP_001005360.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes one of the longer isoforms (1).
    Source sequence(s)
    AC011475, AC011552, AC112707, BC039596, BC054501, BU621654
    Consensus CDS
    CCDS45968.1
    UniProtKB/Swiss-Prot
    A8K1B6, E7EV30, E9PEQ4, K7ESI9, P50570, Q5I0Y0, Q7Z5S3, Q9UPH4
    Related
    ENSP00000347890.6, ENST00000355667.11
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:737868
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651739
    GED; Dynamin GTPase effector domain
  2. NM_001005361.3NP_001005361.1  dynamin-2 isoform 2

    See identical proteins and their annotated locations for NP_001005361.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region, compared to isoform 1.
    Source sequence(s)
    AC011475, AC011552, AC112707, AK097875, BC039596
    Consensus CDS
    CCDS45969.1
    UniProtKB/Swiss-Prot
    P50570
    UniProtKB/TrEMBL
    Q8N1K8
    Related
    ENSP00000373905.4, ENST00000389253.9
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:737868
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651739
    GED; Dynamin GTPase effector domain
  3. NM_001005362.3NP_001005362.1  dynamin-2 isoform 4

    See identical proteins and their annotated locations for NP_001005362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is shorter, compared to isoform 1.
    Source sequence(s)
    AC011475, AC011552, AC112707, AK289831, BC039596, BU621654
    Consensus CDS
    CCDS32908.1
    UniProtKB/Swiss-Prot
    P50570
    Related
    ENSP00000386192.3, ENST00000408974.8
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:733864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain
  4. NM_001190716.2NP_001177645.1  dynamin-2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks 3 nts at an alternate splice site, compared to variant 1. The resulting protein (isoform 5) lacks one aa in the C-terminus, compared to isoform 1.
    Source sequence(s)
    AK312260, BC039596, BU621654
    Consensus CDS
    CCDS59351.1
    UniProtKB/Swiss-Prot
    P50570
    Related
    ENSP00000468734.1, ENST00000585892.5
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PRK14951
    Location:745865
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cd01256
    Location:520629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:651739
    GED; Dynamin GTPase effector domain
  5. NM_004945.4NP_004936.2  dynamin-2 isoform 3

    See identical proteins and their annotated locations for NP_004936.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC011475, AC011552, AC112707, BC054501, BU621654
    Consensus CDS
    CCDS32907.1
    UniProtKB/Swiss-Prot
    P50570
    Related
    ENSP00000352721.6, ENST00000359692.10
    Conserved Domains (5) summary
    smart00053
    Location:6245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:733864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:514625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647735
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    10718079..10831903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    10844675..10958914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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