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srp-1 Serpin domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178585, updated on 4-Jan-2025

Summary

Official Symbol
srp-1
Official Full Name
Serpin domain-containing protein
Primary source
WormBase:WBGene00005642
Locus tag
CELE_C05E4.3
See related
AllianceGenome:WB:WBGene00005642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in proteolysis. Located in endoplasmic reticulum. Is expressed in arcade cell and body wall musculature. Human ortholog(s) of this gene implicated in several diseases, including familial encephalopathy with neuroserpin inclusion bodies; intermediate coronary syndrome; peeling skin syndrome 5; thrombophilia (multiple); and toxic shock syndrome. Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINB11 (serpin family B member 11); and SERPINB3 (serpin family B member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See srp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (753283..755124)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor;Serpentine Receptor, class I Neighboring gene Seven TM Receptor Neighboring gene Seven TM Receptor Neighboring gene F-box domain-containing protein Neighboring gene Ovule protein

Interactions

General gene information

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in proteolysis  
Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
is_active_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
Serpin domain-containing protein
NP_503315.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    753283..755124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070914.7NP_503315.1  Serpin domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503315.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE40
    Conserved Domains (1) summary
    cd19581
    Location:11365
    serpinL_nematode; serpin family L, serpin family proteins from nematodes
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