U.S. flag

An official website of the United States government

dop-2 Dopamine receptor 2 [ Caenorhabditis elegans ]

Gene ID: 179347, updated on 4-Jan-2025

Summary

Official Symbol
dop-2
Official Full Name
Dopamine receptor 2
Primary source
WormBase:WBGene00001053
Locus tag
CELE_K09G1.4
See related
AllianceGenome:WB:WBGene00001053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including cellular response to amphetamine; male mating behavior; and regulation of locomotion involved in locomotory behavior. Predicted to be located in membrane and synapse. Predicted to be active in dendrite and plasma membrane. Is expressed in GLR; male-specific anatomical entity; and neurons. Used to study Parkinson's disease and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; movement disease (multiple); and nicotine dependence. Orthologous to several human genes including DRD3 (dopamine receptor D3). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See dop-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (9608556..9614940)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein RER1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Intrinsically Disordered Protein, class C

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables G protein-coupled serotonin receptor activity  
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go PubMed 
enables neurotransmitter receptor activity  
enables protein binding PubMed 
enables signaling receptor activity  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway PubMed 
involved_in G protein-coupled dopamine receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
involved_in G protein-coupled serotonin receptor signaling pathway  
involved_in cellular response to amphetamine PubMed 
involved_in cellular response to nicotine PubMed 
involved_in chemical synaptic transmission  
involved_in negative regulation of dopamine secretion PubMed 
involved_in negative regulation of locomotion involved in locomotory behavior PubMed 
involved_in positive regulation of locomotion involved in locomotory behavior PubMed 
involved_in positive regulation of male mating behavior PubMed 
involved_in regulation of male mating behavior PubMed 
involved_in regulation of neuronal signal transduction PubMed 
involved_in response to food PubMed 
involved_in response to stimulus  
involved_in spicule insertion PubMed 
involved_in synaptic transmission, dopaminergic  
involved_in vulval location PubMed 
Component Evidence Code Pubs
is_active_in dendrite  
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
located_in synapse  

General protein information

Preferred Names
Dopamine receptor 2
NP_001024047.1
  • Confirmed by transcript evidence
NP_001256126.1
  • Confirmed by transcript evidence
NP_001256127.1
  • Confirmed by transcript evidence
NP_001360548.1
  • Confirmed by transcript evidence
NP_001360549.1
  • Confirmed by transcript evidence
NP_001360550.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9608556..9614940
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269197.4NP_001256126.1  Dopamine receptor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A486WWQ7, A0A486WXI1, A0A486WYH7, E7EM37, G5EBI6, G5EEM7, H2L2G2
    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:751781
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:745828
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001269198.4NP_001256127.1  Dopamine receptor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256127.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2G2
    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:636666
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:630713
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001028876.4NP_001024047.1  Dopamine receptor 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEM7
    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:610635
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:601684
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  4. NM_001373078.2NP_001360550.1  Dopamine receptor 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:602632
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:596679
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  5. NM_001373077.2NP_001360548.1  Dopamine receptor 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:631661
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:625708
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  6. NM_001373076.2NP_001360549.1  Dopamine receptor 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd15053
    Location:38233
    7tmA_D2-like_dopamine_R; D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
    cd14964
    Location:746776
    7tm_GPCRs; TM helix 6 [structural motif]
    cl28897
    Location:740823
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
External link. Please review our privacy policy.