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act-1 Actin-1 [ Caenorhabditis elegans ]

Gene ID: 179535, updated on 25-Apr-2024

Summary

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Gene symbol
act-1
Gene description
Actin-1
Primary source
WormBase:WBGene00000063
Locus tag
CELE_T04C12.6
See related
AllianceGenome:WB:WBGene00000063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cytoskeleton. Involved in cortical actin cytoskeleton organization; embryo development; and mitotic cytokinesis. Located in striated muscle thin filament. Is expressed in Psub4; Z2; Z3; body wall musculature; and gonad. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to several human genes including ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (11081052..11082415)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mammalian cells can trans-splice. But do they? Blumenthal T. Bioessays, 1993 May. PMID 8343144
  2. Mutations in Caenorhabditis elegans actin, which are equivalent to human cardiomyopathy mutations, cause abnormal actin aggregation in nematode striated muscle. Hayashi Y, et al. F1000Res, 2019. PMID 30984387, Free PMC Article
  3. ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation. MacQueen AJ, et al. Mol Biol Cell, 2005 Jul. PMID 15872090, Free PMC Article
  4. Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway. Lažetić V, et al. PLoS Genet, 2018 Apr. PMID 29608564, Free PMC Article
  5. A variant Tc4 transposable element in the nematode C. elegans could encode a novel protein. Li W, et al. Nucleic Acids Res, 1993 Jan 11. PMID 8382791, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly.
    Title: Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cortical actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle thin filament IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Actin-1
NP_505819.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11081052..11082415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073418.9 → NP_505819.1  Actin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505819.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P0DM41, P0DM42, P10983, P10985
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DM41.1
P0DM42.1

Gene LinkOut

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