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C27A7.3 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [ Caenorhabditis elegans ]

Gene ID: 179665, updated on 23-Nov-2023

Summary

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Gene symbol
C27A7.3
Gene description
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3
Primary source
WormBase:WBGene00007755
Locus tag
CELE_C27A7.3
See related
AllianceGenome:WB:WBGene00007755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1) and ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (12140925..12144293)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein Neighboring gene pseudo Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ShKT domain-containing protein;Thrombospondin type 1 domain protein Neighboring gene ShKT domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in striated muscle dense body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3
NP_001041087.1
  • Partially confirmed by transcript evidence
NP_001041088.1
  • Partially confirmed by transcript evidence
NP_001256406.1
  • Confirmed by transcript evidence
NP_001256407.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12140925..12144293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269477.4 → NP_001256406.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256406.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W744
    Conserved Domains (2) summary
    pfam01663
    Location:81 → 386
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:79 → 426
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. NM_001047622.3 → NP_001041087.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041087.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90755, Q1NZ14
    Conserved Domains (2) summary
    pfam01663
    Location:81 → 386
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:79 → 426
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. NM_001269478.3 → NP_001256407.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256407.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W745
    Conserved Domains (2) summary
    pfam01663
    Location:51 → 356
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:49 → 396
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  4. NM_001047623.4 → NP_001041088.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041088.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90755
    Conserved Domains (2) summary
    pfam01663
    Location:51 → 356
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:49 → 396
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90755.3

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