U.S. flag

An official website of the United States government

cpl-1 Cathepsin L-like [ Caenorhabditis elegans ]

Gene ID: 180111, updated on 4-Jan-2025

Summary

Official Symbol
cpl-1
Official Full Name
Cathepsin L-like
Primary source
WormBase:WBGene00000776
Locus tag
CELE_T03E6.7
See related
AllianceGenome:WB:WBGene00000776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Is expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See cpl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (16592572..16595346, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene ncRNA Neighboring gene tRNA-Gln Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasm PubMed 
located_in endolysosome PubMed 
located_in endosome  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
is_active_in lysosome  
located_in lysosome  
located_in phagocytic vesicle  
located_in phagolysosome PubMed 
located_in vesicle lumen PubMed 
located_in yolk granule PubMed 

General protein information

Preferred Names
Cathepsin L-like
NP_001256718.1
  • Confirmed by transcript evidence
NP_001256719.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16592572..16595346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269789.4NP_001256718.1  Cathepsin L-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G333, O45734
    Conserved Domains (2) summary
    pfam00112
    Location:120335
    Peptidase_C1; Papain family cysteine protease
    pfam08246
    Location:3291
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
  2. NM_001269790.3NP_001256719.1  Cathepsin L-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256719.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G333
    Conserved Domains (1) summary
    pfam00112
    Location:1196
    Peptidase_C1; Papain family cysteine protease
External link. Please review our privacy policy.