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Nfil3 nuclear factor, interleukin 3, regulated [ Mus musculus (house mouse) ]

Gene ID: 18030, updated on 12-May-2024

Summary

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Official Symbol
Nfil3provided by MGI
Official Full Name
nuclear factor, interleukin 3, regulatedprovided by MGI
Primary source
MGI:MGI:109495
See related
Ensembl:ENSMUSG00000056749 AllianceGenome:MGI:109495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E4BP4
Summary
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses Per1 and Per2 expression and therefore plays a role in the regulation of circadian rhythm. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 2.7), CNS E14 (RPKM 2.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 27.68 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (53121245..53136914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52967209..52982878, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase Neighboring gene STARR-seq mESC enhancer starr_34553 Neighboring gene STARR-positive B cell enhancer ABC_E3081 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53024873-53025174 Neighboring gene STARR-seq mESC enhancer starr_34554 Neighboring gene STARR-positive B cell enhancer ABC_E4070 Neighboring gene predicted gene, 40950 Neighboring gene STARR-seq mESC enhancer starr_34555 Neighboring gene predicted gene, 33424 Neighboring gene predicted gene, 33519 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53204966-53205267 Neighboring gene STARR-seq mESC enhancer starr_34558 Neighboring gene receptor tyrosine kinase-like orphan receptor 2 Neighboring gene predicted gene, 52058

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice. Wang S, et al. Diabetes, 2023 Mar 1. PMID 36508222, Free PMC Article
  2. NFIL3 deficiency alleviates EAE through regulating different immune cell subsets. Chen Z, et al. J Adv Res, 2022 Jul. PMID 35777910, Free PMC Article
  3. E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice. Wang Z, et al. Drug Metab Dispos, 2022 May. PMID 35246462
  4. Cutaneous Squamous Cell Carcinoma Development Is Associated with a Temporal Infiltration of ILC1 and NK Cells with Immune Dysfunctions. Luci C, et al. J Invest Dermatol, 2021 Oct. PMID 33831432
  5. Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress. Yang M, et al. FASEB J, 2020 Oct. PMID 32780887, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function.
    Title: The transcription factor NFIL3/E4BP4 regulates the developmental stage-specific acquisition of basophil function.
  2. CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
    Title: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
  3. High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.
    Title: High-Fat Diet-Induced DeSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.
  4. NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.
    Title: NFIL3 deficiency alleviates EAE through regulating different immune cell subsets.
  5. E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice.
    Title: E4BP4 Regulates Hepatic Solute Carrier Family 2 Member 9 and Uric Acid Disposition in Mice.
  6. Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.
    Title: Hepatic E4BP4 induction promotes lipid accumulation by suppressing AMPK signaling in response to chemical or diet-induced ER stress.
  7. E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
    Title: E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
  8. The ILC3s are attuned to circadian rhythm, but clock regulator REV-ERBalpha also has circadian-independent impacts on ILC3 development and functions due to its roles in the regulation of RORgammat.
    Title: Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells.
  9. The data indicate that NFIL3 impairs Regulatory T (Treg) cell function through the downregulation of Foxp3 expression.
    Title: The transcription factor NFIL3 controls regulatory T-cell function and stability.
  10. D-box-mediated transcriptional regulation plays pivotal roles in input and output in the circadian clock system.
    Title: Functional D-box sequences reset the circadian clock and drive mRNA rhythms.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nuclear factor interleukin-3-regulated protein
Names
E4 promoter-binding protein 4
embryo implantation-related NFIL3/E4BP4-like transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017373.3 → NP_059069.1  nuclear factor interleukin-3-regulated protein

    See identical proteins and their annotated locations for NP_059069.1

    Status: VALIDATED

    Source sequence(s)
    AK087541, BB872092, BC031377, BQ899715
    Consensus CDS
    CCDS26519.1
    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Related
    ENSMUSP00000065363.8, ENSMUST00000071065.8
    Conserved Domains (2) summary
    cd14694
    Location:72 → 131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130 → 461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    53121245..53136914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516877.3 → XP_006516940.1  nuclear factor interleukin-3-regulated protein isoform X1

    See identical proteins and their annotated locations for XP_006516940.1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72 → 131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130 → 461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

  2. XM_036157903.1 → XP_036013796.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72 → 131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130 → 461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor

  3. XM_017315418.2 → XP_017170907.1  nuclear factor interleukin-3-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    O08750, Q3ULK2, Q497U0
    Conserved Domains (2) summary
    cd14694
    Location:72 → 131
    bZIP_NFIL3; Basic leucine zipper (bZIP) domain of Nuclear factor interleukin-3-regulated protein (NFIL3): a DNA-binding and dimerization domain
    pfam06529
    Location:130 → 461
    Vert_IL3-reg_TF; Vertebrate interleukin-3 regulated transcription factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08750.1 GenPept UniProtKB/Swiss-Prot:O08750

Gene LinkOut

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