cht-1 putative endochitinase [Caenorhabditis elegans] - Gene

Summary

Gene symbol: cht-1
Gene description: putative endochitinase
Primary source: WormBase:WBGene00000503
Locus tag: CELE_C04F6.3
See related: AllianceGenome:WB:WBGene00000503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables chitinase activity. Involved in chitin catabolic process and response to fungus. Predicted to be active in extracellular region. Is expressed in gonad. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Crystal Structure and Structure-Based Discovery of Inhibitors of the Nematode Chitinase CeCht1.
Title: Crystal Structure and Structure-Based Discovery of Inhibitors of the Nematode Chitinase CeCht1.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables chitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATF6-mediated unfolded protein response	HEP more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chitin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in metabolic process	IEA Inferred from Electronic Annotation more info
involved_in polysaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to fungus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

NP_508588.1

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