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paf-2 Platelet-activating factor acetylhydrolase homolog 2 [ Caenorhabditis elegans ]

Gene ID: 180704, updated on 25-Apr-2024

Summary

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Gene symbol
paf-2
Gene description
Platelet-activating factor acetylhydrolase homolog 2
Primary source
WormBase:WBGene00003907
Locus tag
CELE_C52B9.7
See related
AllianceGenome:WB:WBGene00003907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity. Involved in lipid catabolic process and morphogenesis of embryonic epithelium. Predicted to be located in cytosol and endoplasmic reticulum membrane. Is expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); glomerulonephritis (multiple); hemolytic-uremic syndrome; proteinuria (multiple); and type 2 diabetes mellitus. Orthologous to human PLA2G7 (phospholipase A2 group VII) and PAFAH2 (platelet activating factor acetylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (4291475..4294352, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ETS domain-containing protein Neighboring gene ncRNA Neighboring gene ETS class transcription factor Neighboring gene Choline kinase A2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans. Inoue T, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15340150, Free PMC Article
  2. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PAF-AH (II) is predominantly expressed in epithelial cells of C. elegans. This study demonstrates that PAF-AH (II) is essential for epithelial morphogenesis.
    Title: Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in Caenorhabditis elegans.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Platelet-activating factor acetylhydrolase homolog 2
NP_001379717.1
  • Partially confirmed by transcript evidence
NP_741768.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4291475..4294352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171668.10 → NP_741768.1  Platelet-activating factor acetylhydrolase homolog 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22943
    Conserved Domains (1) summary
    pfam03403
    Location:4 → 372
    PAF-AH_p_II; Platelet-activating factor acetylhydrolase, isoform II

  2. NM_001392759.1 → NP_001379717.1  Platelet-activating factor acetylhydrolase homolog 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21494
    Location:4 → 186
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22943.2

Gene LinkOut

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