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acr-3 Acetylcholine receptor subunit beta-type acr-3 [ Caenorhabditis elegans ]

Gene ID: 180937, updated on 4-Jan-2025

Summary

Official Symbol
acr-3
Official Full Name
Acetylcholine receptor subunit beta-type acr-3
Primary source
WormBase:WBGene00000043
Locus tag
CELE_K11G12.7
See related
AllianceGenome:WB:WBGene00000043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit) and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See acr-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (6709538..6712925)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Acetylcholine receptor subunit beta-type acr-2 Neighboring gene ncRNA Neighboring gene Zinc metalloproteinase nas-11 Neighboring gene NRAMP-like transporter smf-2 Neighboring gene NRAMP-like transporter smf-1

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
part_of acetylcholine-gated channel complex  
located_in membrane  
is_active_in neuron projection  
is_active_in plasma membrane  
located_in plasma membrane  
located_in postsynaptic membrane  
is_active_in synapse  
located_in synapse  

General protein information

Preferred Names
Acetylcholine receptor subunit beta-type acr-3
NP_509129.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6709538..6712925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076728.4NP_509129.1  Acetylcholine receptor subunit beta-type acr-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93149
    Conserved Domains (3) summary
    TIGR00860
    Location:5460
    LIC; Cation transporter family protein
    pfam02931
    Location:26226
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:234456
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
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