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plc-1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

Gene ID: 181274, updated on 22-May-2024

Summary

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Gene symbol
plc-1
Gene description
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C
Primary source
WormBase:WBGene00004036
Locus tag
CELE_F31B12.1
See related
AllianceGenome:WB:WBGene00004036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase inhibitor activity; phosphatidylinositol phospholipase C activity; and small GTPase binding activity. Involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process; defense response to Gram-positive bacterium; and positive regulation of protein import into nucleus. Is expressed in several structures, including excretory system; intestine; neurons; spermatheca; and vulva. Human ortholog(s) of this gene implicated in nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See plc-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
69
Sequence:
Chromosome: X; NC_003284.9 (10794857..10838650, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene SCP domain-containing protein Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene tRNA-Glu Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Syndecan Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans. Kunitomo H, et al. Nat Commun, 2013. PMID 23887678
  2. FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange. Goehring NW, et al. Biophys J, 2010 Oct 20. PMID 20959084, Free PMC Article
  3. Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Kariya K, et al. Dev Biol, 2004 Oct 1. PMID 15355798
  4. FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans. Kovacevic I, et al. Dev Biol, 2010 Nov 15. PMID 20707996, Free PMC Article
  5. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, et al. Biol Open, 2012 Mar 15. PMID 23213416, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using genetic analysis and a calcium-sensitive fluorescent protein, we show that FLN-1 functions with PLC-1 to regulate IP3 production, calcium release, and contraction of the spermatheca
    Title: Filamin and phospholipase C-ε are required for calcium signaling in the Caenorhabditis elegans spermatheca.
  2. Phospholipase Cepsilon (plc-1)regulates ovulation in Caenorhabditis elegans.
    Title: Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1;Phosphoinositide phospholipase C
NP_001024617.1
  • Confirmed by transcript evidence
NP_001024619.1
  • Confirmed by transcript evidence
NP_001123141.2
  • Partially confirmed by transcript evidence
NP_001129926.1
  • Confirmed by transcript evidence
NP_001129927.1
  • Confirmed by transcript evidence
NP_001359720.1
  • Partially confirmed by transcript evidence
NP_001360635.1
  • Partially confirmed by transcript evidence
NP_001360636.1
  • Partially confirmed by transcript evidence
NP_001360637.1
  • Partially confirmed by transcript evidence
NP_001360638.1
  • Partially confirmed by transcript evidence
NP_001360639.1
  • Partially confirmed by transcript evidence
NP_509805.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    10794857..10838650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029448.6 → NP_001024619.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024619.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFI8
    Conserved Domains (7) summary
    cd00275
    Location:1408 → 1529
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:909 → 1373
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:840 → 1529
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:62 → 333
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00314
    Location:1572 → 1664
    RA; Ras association (RalGDS/AF-6) domain
    pfam09279
    Location:842 → 903
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:1740 → 1840
    UBQ; Ubiquitin-like proteins

  2. NM_001029446.3 → NP_001024617.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ED55, G5EEI0, G5EEJ6, G5EFI5, G5EFI8
    Conserved Domains (7) summary
    cd00275
    Location:1408 → 1529
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:909 → 1373
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:840 → 1529
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:62 → 333
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00314
    Location:1572 → 1664
    RA; Ras association (RalGDS/AF-6) domain
    pfam09279
    Location:842 → 903
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:1740 → 1855
    UBQ; Ubiquitin-like proteins

  3. NM_077404.6 → NP_509805.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509805.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFI8
    Conserved Domains (7) summary
    cd00275
    Location:1408 → 1529
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:909 → 1373
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:840 → 1529
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:62 → 333
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00314
    Location:1572 → 1664
    RA; Ras association (RalGDS/AF-6) domain
    pfam09279
    Location:842 → 903
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:1738 → 1838
    UBQ; Ubiquitin-like proteins

  4. NM_001373489.2 → NP_001360637.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IMY5
    Conserved Domains (9) summary
    cd08596
    Location:2528 → 2992
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2459 → 3148
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1681 → 1952
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1354 → 1531
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2334 → 2514
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3354 → 3457
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3188 → 3282
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. NM_001129669.4 → NP_001123141.2  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IJW2
    Conserved Domains (9) summary
    cd08596
    Location:2535 → 2999
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2466 → 3155
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1688 → 1959
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1361 → 1538
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2341 → 2521
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3361 → 3464
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3195 → 3289
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. NM_001373491.2 → NP_001360639.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IK11
    Conserved Domains (9) summary
    cd08596
    Location:2538 → 3002
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2469 → 3158
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1691 → 1962
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1364 → 1541
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2344 → 2524
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3364 → 3467
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3198 → 3292
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  7. NM_001373492.2 → NP_001360635.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKD8
    Conserved Domains (9) summary
    cd08596
    Location:2545 → 3009
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2476 → 3165
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1698 → 1969
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1371 → 1548
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2351 → 2531
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3371 → 3474
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3205 → 3299
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  8. NM_001373493.2 → NP_001360636.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IN51
    Conserved Domains (9) summary
    cd08596
    Location:2585 → 3049
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2516 → 3205
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1738 → 2009
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1411 → 1588
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2391 → 2571
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3411 → 3514
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3245 → 3339
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  9. NM_001373494.2 → NP_001359720.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (9) summary
    cd08596
    Location:2592 → 3056
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2523 → 3212
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1745 → 2016
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1418 → 1595
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2398 → 2578
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3418 → 3521
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3252 → 3346
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  10. NM_001373495.2 → NP_001360638.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M3C0
    Conserved Domains (9) summary
    cd08596
    Location:2595 → 3059
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:2526 → 3215
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:1748 → 2019
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00295
    Location:1421 → 1598
    B41; Band 4.1 homologues
    sd00045
    Location:193 → 219
    ANK; ANK repeat [structural motif]
    cd16203
    Location:2401 → 2581
    EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
    cd01780
    Location:3421 → 3524
    RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
    pfam12796
    Location:193 → 328
    Ank_2; Ankyrin repeats (3 copies)
    cl28922
    Location:3255 → 3349
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  11. NM_001136454.3 → NP_001129926.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129926.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFI8
    Conserved Domains (7) summary
    cd00275
    Location:1418 → 1539
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:919 → 1383
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:850 → 1539
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:62 → 333
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00314
    Location:1582 → 1674
    RA; Ras association (RalGDS/AF-6) domain
    pfam09279
    Location:852 → 913
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:1748 → 1848
    UBQ; Ubiquitin-like proteins

  12. NM_001136455.4 → NP_001129927.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFG8
    Conserved Domains (7) summary
    cd00275
    Location:1426 → 1547
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08596
    Location:927 → 1391
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:858 → 1547
    PLN02952; phosphoinositide phospholipase C
    smart00147
    Location:80 → 351
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00314
    Location:1590 → 1682
    RA; Ras association (RalGDS/AF-6) domain
    pfam09279
    Location:860 → 921
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl00155
    Location:1756 → 1856
    UBQ; Ubiquitin-like proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFI8.1

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