U.S. flag

An official website of the United States government

pgp-3 Multidrug resistance protein pgp-3 [ Caenorhabditis elegans ]

Gene ID: 181326, updated on 4-Jan-2025

Summary

Official Symbol
pgp-3
Official Full Name
Multidrug resistance protein pgp-3
Primary source
WormBase:WBGene00003997
Locus tag
CELE_ZK455.7
See related
AllianceGenome:WB:WBGene00003997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to Gram-negative bacterium; innate immune response; and stress response to cadmium ion. Located in apical plasma membrane. Is expressed in excretory cell; intestine; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See pgp-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (11352156..11357094)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Cytoplasmic aconitate hydratase Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene P-GlycoProtein related Neighboring gene ncRNA Neighboring gene Protein tweety homolog 1

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity  
enables ABC-type xenobiotic transporter activity  
enables ATP binding  
enables ATP hydrolysis activity  
enables ATPase-coupled transmembrane transporter activity  
enables efflux transmembrane transporter activity  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium PubMed 
involved_in innate immune response PubMed 
involved_in response to chemical  
involved_in response to metal ion PubMed 
involved_in stress response to cadmium ion PubMed 
involved_in transmembrane transport  
involved_in transmembrane transport  
involved_in xenobiotic transport  
Component Evidence Code Pubs
located_in apical plasma membrane PubMed 
is_active_in membrane  
located_in membrane  
located_in plasma membrane  

General protein information

Preferred Names
Multidrug resistance protein pgp-3
NP_509901.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11352156..11357094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077500.5NP_509901.1  Multidrug resistance protein pgp-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34713, Q20335
    Conserved Domains (3) summary
    cd03249
    Location:10291266
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:1051264
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:50326
    ABC_membrane; ABC transporter transmembrane region
External link. Please review our privacy policy.