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Oaz2 ornithine decarboxylase antizyme 2 [ Mus musculus (house mouse) ]

Gene ID: 18247, updated on 7-May-2024

Summary

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Official Symbol
Oaz2provided by MGI
Official Full Name
ornithine decarboxylase antizyme 2provided by MGI
Primary source
MGI:MGI:109492
See related
Ensembl:ENSMUSG00000040652 AllianceGenome:MGI:109492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AZ2; AZ-2; Sez15; Oaz2-ps
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in lung adult (RPKM 83.1), CNS E18 (RPKM 58.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Oaz2 in Genome Data Viewer
Location:
9 C; 9 35.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65583830..65597582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65676548..65690300)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24463 Neighboring gene STARR-seq mESC enhancer starr_24464 Neighboring gene predicted pseudogene 10144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65469333-65469516 Neighboring gene STARR-seq mESC enhancer starr_24467 Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene zinc finger protein 609 Neighboring gene STARR-seq mESC enhancer starr_24471 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Subcellular localization and phosphorylation of antizyme 2. Murai N, et al. J Cell Biochem, 2009 Nov 1. PMID 19725046
  2. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. Murakami Y, et al. Amino Acids, 2010 Feb. PMID 19997757
  3. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Ivanov IP, et al. Genomics, 1998 Sep 1. PMID 9782076
  4. Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Ivanov IP, et al. Nucleic Acids Res, 2000 Sep 1. PMID 10954585, Free PMC Article
  5. Molecular characterization of seizure-related genes isolated by differential screening. Kajiwara K, et al. Biochem Biophys Res Commun, 1996 Feb 27. PMID 8645260

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The level of AZ2 mRNA decreased during mammary gland development.
    Title: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland.
  2. The protein product is generated using polyamine-regulated programmed ribosomal frameshifting.
    Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase inhibitor activity IGI
Inferred from Genetic Interaction
more info
  
enables ornithine decarboxylase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
  
Process Evidence Code Pubs
involved_in negative regulation of polyamine transmembrane transport IDA
Inferred from Direct Assay
more info
  
acts_upstream_of_or_within polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polyamine metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine decarboxylase antizyme 2
Names
ODC-Az 2
antizyme 2
seizure-related protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301307.1 → NP_001288236.1  ornithine decarboxylase antizyme 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    AK169243, BC083114, CJ072367
    UniProtKB/TrEMBL
    J3QNN0
    Conserved Domains (1) summary
    pfam02100
    Location:97 → 180
    ODC_AZ; Ornithine decarboxylase antizyme

  2. NM_010952.3 → NP_035082.1  ornithine decarboxylase antizyme 2 isoform 1

    See identical proteins and their annotated locations for NP_035082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK169243, BC083114
    Consensus CDS
    CCDS57683.1
    UniProtKB/Swiss-Prot
    O08608
    UniProtKB/TrEMBL
    J3QNN0
    Related
    ENSMUSP00000136914.2, ENSMUST00000153700.9
    Conserved Domains (1) summary
    pfam02100
    Location:98 → 181
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    65583830..65597582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08608.2 GenPept UniProtKB/Swiss-Prot:O08608

Gene LinkOut

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