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asah-2 putative acid ceramidase [ Caenorhabditis elegans ]

Gene ID: 185021, updated on 22-May-2024

Summary

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Gene symbol
asah-2
Gene description
putative acid ceramidase
Primary source
WormBase:WBGene00009192
Locus tag
CELE_F27E5.1
See related
AllianceGenome:WB:WBGene00009192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable N-acylsphingosine amidohydrolase activity. Predicted to be involved in fatty acid metabolic process and sphingolipid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See asah-2 in Genome Data Viewer
Location:
chromosome: II
Exon count:
8
Sequence:
Chromosome: II; NC_003280.10 (10139590..10141406)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Growth arrest-specific protein 1 homolog Neighboring gene Uncharacterized protein Neighboring gene Paired box protein 3 homolog Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Pan CL, et al. Dev Cell, 2008 Jan. PMID 18160346, Free PMC Article
  2. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
  3. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N-acylsphingosine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylsphingosine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid amide hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative acid ceramidase
NP_496187.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    10139590..10141406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_063786.4 → NP_496187.1  putative acid ceramidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_496187.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q09551
    Conserved Domains (2) summary
    cd01903
    Location:138 → 385
    Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
    pfam15508
    Location:52 → 143
    NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q09551.1

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