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Pcsk2 proprotein convertase subtilisin/kexin type 2 [ Mus musculus (house mouse) ]

Gene ID: 18549, updated on 4-Jan-2025

Summary

Official Symbol
Pcsk2provided by MGI
Official Full Name
proprotein convertase subtilisin/kexin type 2provided by MGI
Primary source
MGI:MGI:97512
See related
Ensembl:ENSMUSG00000027419 AllianceGenome:MGI:97512
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC2; Nec2; SPC2; Nec-2; Phpp-2; 6330411F23Rik
Summary
Enables serine-type endopeptidase activity. Involved in nervous system development and protein processing. Acts upstream of or within proteolysis. Located in extracellular space. Is active in secretory granule. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cortex adult (RPKM 46.1), frontal lobe adult (RPKM 33.5) and 4 other tissues See more
Orthologs
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Genomic context

See Pcsk2 in Genome Data Viewer
Location:
2 G1; 2 70.89 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143388053..143658204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143546133..143816284)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33599 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_05885 Neighboring gene STARR-seq mESC enhancer starr_05886 Neighboring gene STARR-seq mESC enhancer starr_05887 Neighboring gene STARR-seq mESC enhancer starr_05889 Neighboring gene proprotein convertase subtilisin/kexin type 2, opposite strand 2 Neighboring gene predicted gene, 52527 Neighboring gene STARR-positive B cell enhancer ABC_E4506 Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene ribosomal protein S13, pseudogene 6 Neighboring gene predicted gene, 33648

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in dendrite  
located_in dendrite  
located_in endoplasmic reticulum lumen  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in intracellular membrane-bounded organelle  
is_active_in membrane  
located_in membrane  
located_in membrane  
is_active_in neuron projection  
located_in neuronal cell body  
located_in nucleoplasm  
located_in nucleoplasm  
located_in perikaryon  
located_in perikaryon  
is_active_in secretory granule PubMed 
located_in secretory granule  
located_in secretory granule lumen  
located_in transport vesicle  

General protein information

Preferred Names
neuroendocrine convertase 2
Names
KEX2-like endoprotease 2
NEC 2
prohormone convertase 2
proprotein convertase 2
NP_032818.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008792.4NP_032818.1  neuroendocrine convertase 2 precursor

    See identical proteins and their annotated locations for NP_032818.1

    Status: VALIDATED

    Source sequence(s)
    AK158598, AL807801, BC057348
    Consensus CDS
    CCDS16810.1
    UniProtKB/Swiss-Prot
    P21661, Q80WU1
    UniProtKB/TrEMBL
    Q3TYM6, Q547J8
    Related
    ENSMUSP00000028905.10, ENSMUST00000028905.10
    Conserved Domains (4) summary
    cd04059
    Location:121417
    Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
    pfam00082
    Location:157434
    Peptidase_S8; Subtilase family
    pfam01483
    Location:503590
    P_proprotein; Proprotein convertase P-domain
    pfam16470
    Location:32108
    S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    143388053..143658204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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