Padi3 peptidyl arginine deiminase, type III [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Padi3provided by MGI
Official Full Name: peptidyl arginine deiminase, type IIIprovided by MGI
Primary source: MGI:MGI:1338891
See related: Ensembl:ENSMUSG00000025328 AllianceGenome:MGI:1338891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pad3; Pdi3; mKIAA4171
Summary: Predicted to enable identical protein binding activity and protein-arginine deiminase activity. Predicted to be involved in histone citrullination. Predicted to be active in cytoplasm and nucleus. Is expressed in blastocyst; early embryo; ganglia; oocyte; and vibrissa. Orthologous to human PADI3 (peptidyl arginine deiminase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 1.0), thymus adult (RPKM 1.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 72.5 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (140512680..140537959, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (140785369..140810648, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
Title: Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
The two enzymes PADI3 and TGM3, responsible for posttranslational protein modifications, and their target structural protein TCHH are all involved in hair shaft formation.
Title: Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Spontaneous (1) 1 citation
Targeted (3)

General gene information

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Markers

AI507004 (e-PCR)
- UniSTS:185607

Padi3 (e-PCR), detects polymorphism
- UniSTS:546914

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-arginine deiminase activity	ISO Inferred from Sequence Orthology more info
enables protein-arginine deiminase activity	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein-arginine deiminase type-3

Names: PAD type III; PROTEIN-ARGININE DEIMINASE TYPE III (PEPTIDYLARGININE DEIMINASE III); peptidylarginine deiminase III

NP_035190.3

EC 3.5.3.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011060.4 → NP_035190.3 protein-arginine deiminase type-3

See identical proteins and their annotated locations for NP_035190.3

Status: VALIDATED

Source sequence(s)

AB013849, AK220522, AL807805

Consensus CDS

CCDS18855.1

UniProtKB/Swiss-Prot

A2AMU4, Q9Z184

UniProtKB/TrEMBL

Q75WC8

Related

ENSMUSP00000026377.3, ENSMUST00000026377.9

Conserved Domains (3) summary

pfam03068
Location:286 → 661

PAD; Protein-arginine deiminase (PAD)

pfam08526
Location:1 → 113

PAD_N; Protein-arginine deiminase (PAD) N-terminal domain

pfam08527
Location:115 → 272

PAD_M; Protein-arginine deiminase (PAD) middle domain