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Prkci protein kinase C, iota [ Mus musculus (house mouse) ]

Gene ID: 18759, updated on 4-Jan-2025

Summary

Official Symbol
Prkciprovided by MGI
Official Full Name
protein kinase C, iotaprovided by MGI
Primary source
MGI:MGI:99260
See related
Ensembl:ENSMUSG00000037643 AllianceGenome:MGI:99260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkci; Pkcl; Prkcl; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik
Summary
Enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity. Involved in cellular response to insulin stimulus; positive regulation of D-glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and brush border. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in bladder adult (RPKM 26.7), placenta adult (RPKM 19.4) and 28 other tissues See more
Orthologs
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Genomic context

See Prkci in Genome Data Viewer
Location:
3 A3; 3 14.65 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31049893..31106889)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30995742..31052740)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene polyhomeotic 3 Neighboring gene STARR-positive B cell enhancer ABC_E4537 Neighboring gene predicted gene 2979 Neighboring gene STARR-positive B cell enhancer ABC_E4538 Neighboring gene STARR-seq mESC enhancer starr_07307 Neighboring gene STARR-seq mESC enhancer starr_07308 Neighboring gene STARR-seq mESC enhancer starr_07310 Neighboring gene microRNA 7008 Neighboring gene STARR-seq mESC enhancer starr_07312 Neighboring gene predicted gene, 33641 Neighboring gene predicted gene, 33694 Neighboring gene STARR-positive B cell enhancer ABC_E9544 Neighboring gene STARR-positive B cell enhancer ABC_E2067 Neighboring gene STARR-seq mESC enhancer starr_07316 Neighboring gene SKI-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 
  • Targeted (10)  1 citation

Pathways from PubChem

Interactions

General gene information

Clone Names

  • KIAA4165

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent serine/threonine kinase activity  
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity PubMed 
enables metal ion binding  
enables phospholipid binding  
enables phospholipid binding  
enables protein binding PubMed 
enables protein kinase activity  
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
Items 1 - 25 of 37
Process Evidence Code Pubs
involved_in Golgi vesicle budding  
involved_in Golgi vesicle budding  
acts_upstream_of_or_within actin filament organization PubMed 
involved_in cell migration  
involved_in cell migration  
involved_in cell-cell junction organization  
involved_in cell-cell junction organization  
involved_in cellular response to insulin stimulus  
involved_in cellular response to insulin stimulus PubMed 
involved_in cellular response to insulin stimulus  
acts_upstream_of_or_within establishment of apical/basal cell polarity PubMed 
involved_in establishment of cell polarity  
involved_in establishment or maintenance of epithelial cell apical/basal polarity  
involved_in establishment or maintenance of epithelial cell apical/basal polarity  
acts_upstream_of_or_within eye photoreceptor cell development PubMed 
involved_in intracellular signal transduction  
involved_in negative regulation of glial cell apoptotic process  
involved_in negative regulation of glial cell apoptotic process  
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of neuron apoptotic process  
involved_in positive regulation of D-glucose import PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of endothelial cell apoptotic process  
involved_in positive regulation of endothelial cell apoptotic process  
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of protein localization to plasma membrane PubMed 
involved_in protein localization to plasma membrane  
involved_in protein phosphorylation  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
involved_in response to interleukin-1  
involved_in response to interleukin-1  
involved_in response to peptide hormone  
Items 1 - 25 of 37
Items 1 - 20 of 26
Component Evidence Code Pubs
located_in Golgi membrane  
part_of PAR polarity complex  
part_of PAR polarity complex  
located_in Schaffer collateral - CA1 synapse  
is_active_in Schaffer collateral - CA1 synapse  
located_in Schmidt-Lanterman incisure PubMed 
located_in apical part of cell PubMed 
located_in apical plasma membrane PubMed 
located_in bicellular tight junction  
located_in bicellular tight junction  
located_in brush border PubMed 
located_in cell leading edge  
located_in cell leading edge  
located_in cytoplasm PubMed 
located_in cytosol  
located_in cytosol  
located_in endosome  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in intercellular bridge  
located_in intercellular bridge  
located_in microtubule cytoskeleton  
located_in microtubule cytoskeleton  
located_in nucleus PubMed 
located_in nucleus  
located_in nucleus  
Items 1 - 20 of 26

General protein information

Preferred Names
protein kinase C iota type
Names
aPKC-lambda/iota
atypical protein kinase C-lambda/iota
nPKC-iota
protein kinase C, lambda
NP_032883.2
XP_006535474.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428640.1NP_001415569.1  protein kinase C iota type isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC117590
    UniProtKB/TrEMBL
    Q3TJJ5
  2. NM_008857.4NP_032883.2  protein kinase C iota type isoform 1

    See identical proteins and their annotated locations for NP_032883.2

    Status: VALIDATED

    Source sequence(s)
    AC111093, AC117590
    Consensus CDS
    CCDS17289.2
    UniProtKB/Swiss-Prot
    Q62074
    UniProtKB/TrEMBL
    Q3TJJ5
    Related
    ENSMUSP00000103884.3, ENSMUST00000108249.9
    Conserved Domains (3) summary
    cd06404
    Location:26108
    PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...
    cd05618
    Location:232595
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:141193
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    31049893..31106889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535411.5XP_006535474.2  protein kinase C iota type isoform X1

    Conserved Domains (3) summary
    cd05618
    Location:202565
    STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota
    pfam00130
    Location:111161
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02720
    Location:2679
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
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