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lev-9 Protein lev-9 [ Caenorhabditis elegans ]

Gene ID: 188252, updated on 4-Jan-2025

Summary

Official Symbol
lev-9
Official Full Name
Protein lev-9
Primary source
WormBase:WBGene00002976
Locus tag
CELE_T07H6.5
See related
AllianceGenome:WB:WBGene00002976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable peptidase inhibitor activity. Located in extracellular space. Is expressed in body wall musculature; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; IgA glomerulonephritis; atopic dermatitis; cerebrovascular disease (multiple); and coronary artery disease (multiple). Orthologous to several human genes including CR1 (complement C3b/C4b receptor 1 (Knops blood group)); CR1L (complement C3b/C4b receptor 1 like); and C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See lev-9 in Genome Data Viewer
Location:
chromosome: X
Exon count:
27
Sequence:
Chromosome: X; NC_003284.9 (6281847..6291732, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene Protein-serine O-palmitoleoyltransferase porcupine

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in extracellular region  
located_in extracellular space PubMed 
located_in synapse  

General protein information

Preferred Names
Protein lev-9
NP_001335574.1
  • Confirmed by transcript evidence
NP_001335575.1
  • Partially confirmed by transcript evidence
NP_509053.3
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6281847..6291732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348599.3NP_001335574.1  Protein lev-9 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SYU8
    Conserved Domains (3) summary
    cd00033
    Location:64119
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl00156
    Location:1861
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    cl27761
    Location:127363
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  2. NM_001348600.3NP_001335575.1  Protein lev-9 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1N7SZ15
    Conserved Domains (3) summary
    cd00033
    Location:64119
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cl00156
    Location:1861
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    cl27761
    Location:127363
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
  3. NM_076652.8NP_509053.3  Protein lev-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509053.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C7C692, Q22328
    Conserved Domains (4) summary
    cd00033
    Location:193247
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:377557
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:309362
    Sushi; Sushi repeat (SCR repeat)
    cl00156
    Location:1861
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
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