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sqv-6 Xylosyltransferase sqv-6;protein xylosyltransferase [ Caenorhabditis elegans ]

Gene ID: 190099, updated on 22-May-2024

Summary

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Gene symbol
sqv-6
Gene description
Xylosyltransferase sqv-6;protein xylosyltransferase
Primary source
WormBase:WBGene00005024
Locus tag
CELE_Y50D4C.4
See related
AllianceGenome:WB:WBGene00005024
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein xylosyltransferase activity. Involved in several processes, including UDP-D-xylose metabolic process; glycosaminoglycan biosynthetic process; and oviposition. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Orthologous to human XYLT1 (xylosyltransferase 1) and XYLT2 (xylosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See sqv-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (950306..964789, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Survival of motor neuron-related-splicing factor 30;Tudor domain-containing protein Neighboring gene Cysteine dioxygenase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase. Hwang HY, et al. J Biol Chem, 2003 Apr 4. PMID 12584198
  2. Comparative characterisation of recombinant invertebrate and vertebrate peptide O-Xylosyltransferases. Brunner A, et al. Glycoconj J, 2006 Nov. PMID 17006645
  3. Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans. Díaz-Balzac CA, et al. G3 (Bethesda), 2014 Aug 5. PMID 25098771, Free PMC Article
  4. sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination. Herman T, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927677, Free PMC Article
  5. Mutations that perturb vulval invagination in C. elegans. Herman T, et al. Cold Spring Harb Symp Quant Biol, 1997. PMID 9598369

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein xylosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein xylosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein xylosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-D-xylose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chondroitin sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Xylosyltransferase sqv-6;protein xylosyltransferase
NP_001300279.1
  • Confirmed by transcript evidence
NP_001300280.1
  • Confirmed by transcript evidence
NP_503359.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    950306..964789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070958.6 → NP_503359.2  Xylosyltransferase sqv-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503359.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q867S3, Q965Q8
    Conserved Domains (2) summary
    pfam01822
    Location:113 → 195
    WSC; WSC domain
    pfam02485
    Location:246 → 485
    Branch; Core-2/I-Branching enzyme

  2. NM_001313350.3 → NP_001300279.1  protein xylosyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYD4
    Conserved Domains (1) summary
    pfam02485
    Location:9 → 107
    Branch; Core-2/I-Branching enzyme

  3. NM_001313351.3 → NP_001300280.1  Xylosyltransferase sqv-6 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AT40
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965Q8.3

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