Serpina12 serpin family A member 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpina12provided by RGD
Official Full Name: serpin family A member 12provided by RGD
Primary source: RGD:708485
See related: Ensembl:ENSRNOG00000042634 AllianceGenome:RGD:708485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ol64; Ol-64
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in glucose metabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Used to study obesity and type 2 diabetes mellitus. Orthologous to human SERPINA12 (serpin family A member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2.5), Lung (RPKM 1.0) and 5 other tissues See more
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Genomic context

Location:: 6q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (128717334..128732049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (122952552..122967271, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (127696501..127711238, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vaspin regulated cartilage cholesterol metabolism through miR155/LXRalpha and participated in the occurrence of osteoarthritis in rats.
Title: Vaspin regulated cartilage cholesterol metabolism through miR155/LXRα and participated in the occurrence of osteoarthritis in rats.
These results demonstrate that Vaspin alleviates STZ-induced myocardial injury and renders a cardioprotective effect by suppressing NLRP3 inflammasome activation and promoting autophagy.
Title: Vaspin prevents myocardial injury in rats model of diabetic cardiomyopathy by enhancing autophagy and inhibiting inflammation.
in contrast to oxidative stress and inflammatory biomarkers, vaspin level would be a more reliable diagnostic factor when it comes to the insulin resistance
Title: Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon.
These results demonstrated that vaspin prevented leptininduced inflammation and catabolism by inhibiting the activation of NFkappa B in rat chondrocytes.
Title: Vaspin prevents leptin‑induced inflammation and catabolism by inhibiting the activation of nuclear factor‑κB in rat chondrocytes.
We for the first time demonstrate that vaspin augments the acetylcholine -induced nitric oxide-mediated endothelium-dependent relaxation via the inhibition of acetylcholinesterase activity.
Title: Visceral adipose tissue-derived serine protease inhibitor augments acetylcholine-induced relaxation via the inhibition of acetylcholine esterase activity in rat isolated mesenteric artery.
In the chronic intermittent hypoxia rat model, the expression of vaspin in visceral adipose tissues and plasma were increased, which were correlated with insulin resistance.
Title: Vaspin as a Risk Factor of Insulin Resistance in Obstructive Sleep Apnea-Hypopnea Syndrome in an Animal Model.
Variability in serum vaspin concentrations might be explained by its genetic variants.
Title: Genetic variation in the vaspin gene affects circulating serum vaspin concentrations.
Vaspin inhibits glucose-induced vascular smooth muscle cells proliferation and chemokinesis by preventing reactive oxygen species activation and MAPK, PI3K/Akt, and NF-kappaB signaling.
Title: Vaspin attenuates high glucose-induced vascular smooth muscle cells proliferation and chemokinesis by inhibiting the MAPK, PI3K/Akt, and NF-κB signaling pathways.
Vaspin is a novel ligand for the cell-surface GRP78/voltage-dependent anion channel complex in endothelial cells and promotes proliferation, inhibits apoptosis, and protects vascular injuries in diabetes mellitus.
Title: Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex.
Vaspin is presumably an adipocytokine that can increase insulin sensitivity, promote insulin secretion by islet beta-cells and improve glucose tolerance, and it may be involved in insulin resistance and the disturbance of carbohydrate metabolism.
Title: [Correlation between vaspin concentration and insulin sensitivity in the visceral adipose tissue of young obese rats].

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serpin A12

Names: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12; serine (or cysteine) peptidase inhibitor, clade A, member 12; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12; serpin peptidase inhibitor, clade A, member 12; vaspin; visceral adipose tissue-derived serine protease inhibitor; visceral adipose tissue-derived serpin; visceral adipose-specific serpin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138825.2 → NP_620180.2 serpin A12 precursor

See identical proteins and their annotated locations for NP_620180.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q8R4Z1

UniProtKB/TrEMBL

A6JEQ0, G3V782

Related

ENSRNOP00000012960.2, ENSRNOT00000012960.4

Conserved Domains (1) summary

cd02056
Location:51 → 408

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

128717334..128732049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017594028.3 → XP_017449517.1 serpin A12 isoform X1

UniProtKB/Swiss-Prot

Q8R4Z1

UniProtKB/TrEMBL

A6JEQ0, G3V782

Conserved Domains (1) summary

cd02056
Location:51 → 408

alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...