Sftpb surfactant protein B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sftpbprovided by RGD
Official Full Name: surfactant protein Bprovided by RGD
Primary source: RGD:621700
See related: Ensembl:ENSRNOG00000010761 AllianceGenome:RGD:621700
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sp-b
Summary: Involved in several processes, including cellular response to mechanical stimulus; cellular response to nitric oxide; and response to vitamin A. Located in alveolar lamellar body; extracellular space; and multivesicular body. Biomarker of asthma; bacterial pneumonia; lung disease; newborn respiratory distress syndrome; and obesity. Human ortholog(s) of this gene implicated in lung disease (multiple); respiratory syncytial virus infectious disease; and toxic shock syndrome. Orthologous to human SFTPB (surfactant protein B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 5044.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (105917495..105926631)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104359303..104368439)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100166855..100175941)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.
Title: The expression of the surfactant proteins SP-A and SP-B during postnatal alveolarization of the rat lung.
Recombinant expression of the precursor of rat lung surfactant protein B in Escherichia coli and its antibacterial mechanism.
Title: Recombinant expression of the precursor of rat lung surfactant protein B in Escherichia coli and its antibacterial mechanism.
The expression of SP-B and SP-C in GDM group was significantly reduced as compared with control group (P<0.05)... It was concluded that gestational diabetes mellitus can cause fetal lung development and maturation disorders, and FOXA2 in fetal lung tissue decreases while nitrocellulose FOXA2 increases
Title: Expression of Lung Surfactant Proteins SP-B and SP-C and Their Regulatory Factors in Fetal Lung of GDM Rats.
SP-B is present on the surface of exocytosed surfactant particles. Antibodies against SP-B stabilize the released particles when contacting the air-liquid interface, precluding their transformation and the formation of surface films. SP-B acts as an essential, preformed molecular key in the initial stages of surfactant unpacking and surface film formation.
Title: A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies.
Liraglutide activates the GLP1 receptor, increasing ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of Type 1 Diabetes rats
Title: Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats.
The role of the SP-B NH(2) terminus in the formation and stability of cylindrical structures, specifically the distribution of lipid stack height, width, and density with four SP-B truncation peptides, was studied.
Title: Functional importance of the NH2-terminal insertion sequence of lung surfactant protein B.
alterations of surfactant are a consequence of the ventilation strategy that impair the biophysical activity of this material and thereby contribute directly to lung dysfunction over time
Title: Alterations to surfactant precede physiological deterioration during high tidal volume ventilation.
VEGF increased expression of SP-b mRNA in preterm rat lung.
Title: High-dose vascular endothelial growth factor increases surfactant protein gene expressions in preterm rat lung.
Results suggest that there is no primary deficiency of surfactant proteins A, B, or C in the nitrofen-induced rat model of congenital diaphragmatic hernia.
Title: Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model.
Data indicate that heparin can be stimulatory to surfactant protein B and C gene expression depending on concentration, degree of sulfation, and surrounding fibroblast growth factor environment.
Title: Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH142439 (e-PCR)
- UniSTS:231686

PMC34520P1 (e-PCR)
- UniSTS:273210

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in respiratory gaseous exchange by respiratory system	IEA Inferred from Electronic Annotation more info
involved_in response to Thyroglobulin triiodothyronine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to epidermal growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hyperoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-6	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to leptin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in surfactant homeostasis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in alveolar lamellar body	IBA Inferred from Biological aspect of Ancestor more info
located_in alveolar lamellar body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in multivesicular body	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pulmonary surfactant-associated protein B

Names: pulmonary surfactant-associated proteolipid SPL(Phe); surfactant associated protein B; surfactant, pulmonary-associated protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138842.2 → NP_620197.2 pulmonary surfactant-associated protein B precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

P22355

UniProtKB/TrEMBL

F7FPB1, Q6IN44

Related

ENSRNOP00000014505.4, ENSRNOT00000014505.8

Conserved Domains (2) summary

smart00741
Location:65 → 141

SapB; Saposin (B) Domains

cl02494
Location:29 → 59

SapA; Saposin A-type domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

105917495..105926631

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236657.5 → XP_006236719.1 pulmonary surfactant-associated protein B isoform X1

UniProtKB/Swiss-Prot

P22355

Conserved Domains (4) summary

smart00741
Location:65 → 141

SapB; Saposin (B) Domains

pfam03489
Location:110 → 141

SapB_2; Saposin-like type B, region 2

pfam05184
Location:67 → 101

SapB_1; Saposin-like type B, region 1

cl02494
Location:29 → 59

SapA; Saposin A-type domain