Prom2 prominin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prom2provided by RGD
Official Full Name: prominin 2provided by RGD
Primary source: RGD:621435
See related: Ensembl:ENSRNOG00000014710 AllianceGenome:RGD:621435
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trprp; Promrp; Prom-rp
Summary: Enables cholesterol binding activity. Predicted to be involved in several processes, including negative regulation of endocytosis; positive regulation of protein phosphorylation; and regulation of GTPase activity. Located in several cellular components, including microspike; microvillus; and prominosome. Is integral component of plasma membrane. Colocalizes with membrane raft. Orthologous to human PROM2 (prominin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 44.6), Lung (RPKM 9.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (135200944..135215130, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114747654..114761787, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (120087633..120107495, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that prominin-2 prevents the formation of caveolae in normal and ovarian hyperstimulated pregnancy.
Title: Prominin-2 Prevents the Formation of Caveolae in Normal and Ovarian Hyperstimulated Pregnancy.
These data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions.
Title: Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine.
results argue that PROML2 is a novel proapoptotic membrane protein; its down-regulation may associate with aggressive phenotype of prostate cancer cells
Title: Identification and characterization of a novel testosterone-regulated prominin-like gene in the rat ventral prostate.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134252 (e-PCR)
- UniSTS:217534

BM388274 (e-PCR)
- UniSTS:261586

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of caveolin-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of pinocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in microspike	IDA Inferred from Direct Assay more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in prominosome	IBA Inferred from Biological aspect of Ancestor more info
located_in prominosome	IDA Inferred from Direct Assay more info	PubMed
located_in prominosome	IEA Inferred from Electronic Annotation more info
located_in prominosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prominin-2

Names: PROM-2; prominin-like protein 2; prominin-related protein; rPROML2; testosterone-regulated prominin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138857.2 → NP_620212.2 prominin-2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8CJ52, Q8R4B6

UniProtKB/TrEMBL

A6HQ19, F1LQW5

Related

ENSRNOP00000020354.5, ENSRNOT00000020354.6

Conserved Domains (1) summary

pfam05478
Location:27 → 807

Prominin