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Slc9a5 solute carrier family 9 member A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192215, updated on 5-Mar-2024

Summary

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Official Symbol
Slc9a5provided by RGD
Official Full Name
solute carrier family 9 member A5provided by RGD
Primary source
RGD:620473
See related
Ensembl:ENSRNOG00000028844 AllianceGenome:RGD:620473
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nhe5
Summary
Enables sodium:proton antiporter activity. Involved in proton transmembrane transport and sodium ion transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in end stage renal disease. Orthologous to human SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 36.8), Lung (RPKM 16.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc9a5 in Genome Data Viewer
Location:
19q12
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50135973..50156833)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33225481..33246913)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37304034..37325345)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene pleckstrin homology and RhoGEF domain containing G4 Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene leucine rich repeat containing 36

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration. Fan SH, et al. Mol Biol Cell, 2016 Feb 15. PMID 26700318, Free PMC Article
  2. Human Na+/H+ exchanger genes : identification of polymorphisms by radiation hybrid mapping and analysis of linkage in end-stage renal disease. Yu H, et al. Hypertension, 2000 Jan. PMID 10642288
  3. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception. Rocha-González HI, et al. Neuroscience, 2009 Apr 21. PMID 19248819
  4. Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain. Attaphitaya S, et al. J Biol Chem, 1999 Feb 12. PMID 9933642
  5. Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling. Diering GH, et al. Mol Biol Cell, 2013 Nov. PMID 24006492, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHE5 facilitates MET recycling to the plasma membrane, protects MET from degradation, and modulates HGF-induced phosphatidylinositol-3-kinase and mitogen-activated protein kinase signaling.
    Title: Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration.
  2. Data indicate that NHE5 depletion reduces cell surface abundance of TrkA and nerve growth factor (NGF)-induced PI3K signaling.
    Title: Endosomal acidification by Na+/H+ exchanger NHE5 regulates TrkA cell-surface targeting and NGF-induced PI3K signaling.
  3. these data suggest that NHE1, but not NHE5, plays an important role reducing inflammatory pain in rats.
    Title: Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arrestin family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular pH ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine membrane IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron spine ISO
Inferred from Sequence Orthology
more info
  
located_in neuron spine ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 5
Names
NHE-5
Na(+)/H(+) exchanger 5
solute carrier family 9 (sodium/hydrogen exchanger), member 5
solute carrier family 9 member 5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138858.1 → NP_620213.1  sodium/hydrogen exchanger 5 precursor

    See identical proteins and their annotated locations for NP_620213.1

    Status: PROVISIONAL

    Source sequence(s)
    AF100172
    UniProtKB/Swiss-Prot
    G3V9Y4, Q9Z0X2
    Related
    ENSRNOP00000063061.1, ENSRNOT00000068299.2
    Conserved Domains (2) summary
    TIGR00840
    Location:43 → 632
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:52 → 457
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50135973..50156833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601171.3 → XP_017456660.1  sodium/hydrogen exchanger 5 isoform X1

    UniProtKB/Swiss-Prot
    G3V9Y4, Q9Z0X2

  2. XM_039097459.2 → XP_038953387.1  sodium/hydrogen exchanger 5 isoform X3

    Conserved Domains (1) summary
    TIGR00840
    Location:43 → 632
    b_cpa1; sodium/hydrogen exchanger 3

  3. XM_039097460.2 → XP_038953388.1  sodium/hydrogen exchanger 5 isoform X4

    Conserved Domains (1) summary
    TIGR00840
    Location:43 → 622
    b_cpa1; sodium/hydrogen exchanger 3

  4. XM_039097458.2 → XP_038953386.1  sodium/hydrogen exchanger 5 isoform X2

    UniProtKB/Swiss-Prot
    G3V9Y4, Q9Z0X2
    Conserved Domains (2) summary
    TIGR00840
    Location:3 → 570
    b_cpa1; sodium/hydrogen exchanger 3
    pfam03154
    Location:734 → 821
    Atrophin-1; Atrophin-1 family

  5. XM_039097461.2 → XP_038953389.1  sodium/hydrogen exchanger 5 isoform X5

    Conserved Domains (2) summary
    TIGR00840
    Location:1 → 335
    b_cpa1; sodium/hydrogen exchanger 3
    pfam03154
    Location:499 → 586
    Atrophin-1; Atrophin-1 family

RNA

  1. XR_005496609.2 RNA Sequence

  2. XR_010059958.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z0X2.2 GenPept UniProtKB/Swiss-Prot:Q9Z0X2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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