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Golgb1 golgin B1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192243, updated on 3-Apr-2024

Summary

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Official Symbol
Golgb1provided by RGD
Official Full Name
golgin B1provided by RGD
Primary source
RGD:708429
See related
Ensembl:ENSRNOG00000030314 AllianceGenome:RGD:708429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in chondrocyte proliferation. Predicted to be located in Golgi apparatus. Predicted to be active in cis-Golgi network and endoplasmic reticulum-Golgi intermediate compartment. Used to study osteochondrodysplasia. Orthologous to human GOLGB1 (golgin B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 159.9), Lung (RPKM 106.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Golgb1 in Genome Data Viewer
Location:
11q21
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (77348573..77406165, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (63843179..63900665, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (66761646..66819115, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene F-box protein 40 Neighboring gene hematopoietic cell specific Lyn substrate 1 Neighboring gene IQ motif containing B1 Neighboring gene ELL associated factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat. Katayama K, et al. Bone, 2011 Nov. PMID 21851869
  2. Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells. Casey CA, et al. Biomolecules, 2018 Nov 16. PMID 30453527, Free PMC Article
  3. Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis. Katayama K, et al. Biochem Biophys Res Commun, 2018 May 15. PMID 29577904
  4. Characterization of the INT6 mammary tumor gene product. Diella F, et al. DNA Cell Biol, 1997 Jul. PMID 9260927
  5. Subunit composition of the human cytoplasmic dynein-2 complex. Asante D, et al. J Cell Sci, 2014 Nov 1. PMID 25205765, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ethanol-induced Golgi disassembly was associated with de-dimerization of the largest Golgi matrix protein giantin, along with impaired transport of selected hepatic proteins.
    Title: Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells.
  2. giantin plays a pivotal role in coordinated production of aggrecan, link protein and type XI collagen in chondrocytes.
    Title: Giantin is required for coordinated production of aggrecan, link protein and type XI collagen during chondrogenesis.
  3. concluded that mutation of the Golgb1 gene is responsible for the phenotypic characteristics including osteochondrodysplasia of ocd/ocd, and that giantin plays a pivotal role in multiple aspects of chondrogenesis
    Title: Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cis-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
golgin subfamily B member 1
Names
Golgin subfamily B member 1
golgi autoantigen, golgin subfamily b, macrogolgin 1
golgi-associated protein GCP360
golgin B1, golgi integral membrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138885.2 → NP_620240.2  golgin subfamily B member 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A6IRA0, G3V6A8, Q63714
    Related
    ENSRNOP00000003255.3, ENSRNOT00000003255.5
    Conserved Domains (3) summary
    COG1196
    Location:1298 → 2128
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:45 → 114
    alaS; alanyl-tRNA synthetase; Reviewed
    TIGR02168
    Location:679 → 1582
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    77348573..77406165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597867.3 → XP_017453356.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    A6IRA0, G3V6A8, Q63714
    Conserved Domains (3) summary
    COG1196
    Location:1298 → 2128
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:45 → 114
    alaS; alanyl-tRNA synthetase; Reviewed
    TIGR02168
    Location:679 → 1582
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_008768700.4 → XP_008766922.1  golgin subfamily B member 1 isoform X3

    UniProtKB/TrEMBL
    Q63714
    Conserved Domains (3) summary
    COG1196
    Location:1333 → 2163
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:189 → 922
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10211
    Location:1137 → 1203
    Ax_dynein_light; Axonemal dynein light chain

  3. XM_008768699.4 → XP_008766921.1  golgin subfamily B member 1 isoform X2

    UniProtKB/TrEMBL
    Q63714
    Conserved Domains (3) summary
    COG1196
    Location:1334 → 2164
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:715 → 1618
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam10211
    Location:1138 → 1204
    Ax_dynein_light; Axonemal dynein light chain

  4. XM_006248379.5 → XP_006248441.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_006248441.1

    UniProtKB/TrEMBL
    A0A8I5ZUB6
    Related
    ENSRNOP00000069873.2
    Conserved Domains (4) summary
    COG1196
    Location:1339 → 2169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:45 → 114
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:63 → 181
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:720 → 1623
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_063270269.1 → XP_063126339.1  golgin subfamily B member 1 isoform X4

    UniProtKB/TrEMBL
    A6IRA0, G3V6A8

  6. XM_063270268.1 → XP_063126338.1  golgin subfamily B member 1 isoform X3

  7. XM_063270265.1 → XP_063126335.1  golgin subfamily B member 1 isoform X2

  8. XM_006248380.5 → XP_006248442.1  golgin subfamily B member 1 isoform X1

    See identical proteins and their annotated locations for XP_006248442.1

    UniProtKB/TrEMBL
    A0A8I5ZUB6
    Conserved Domains (4) summary
    COG1196
    Location:1339 → 2169
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK00252
    Location:45 → 114
    alaS; alanyl-tRNA synthetase; Reviewed
    PRK12704
    Location:63 → 181
    PRK12704; phosphodiesterase; Provisional
    TIGR02168
    Location:720 → 1623
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_063270267.1 → XP_063126337.1  golgin subfamily B member 1 isoform X3

  10. XM_063270264.1 → XP_063126334.1  golgin subfamily B member 1 isoform X1

  11. XM_063270270.1 → XP_063126340.1  golgin subfamily B member 1 isoform X5

  12. XM_008768703.4 → XP_008766925.2  golgin subfamily B member 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZUB6, Q63714
Nucleotide Protein Strain
Heading Accession and Version

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