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Sub1 SUB1 regulator of transcription [ Rattus norvegicus (Norway rat) ]

Gene ID: 192269, updated on 11-Apr-2024

Summary

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Official Symbol
Sub1provided by RGD
Official Full Name
SUB1 regulator of transcriptionprovided by RGD
Primary source
RGD:621582
See related
Ensembl:ENSRNOG00000067555 AllianceGenome:RGD:621582
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpo2tc1
Summary
Predicted to enable DNA binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in negative regulation of DNA metabolic process and positive regulation of transcription initiation from RNA polymerase II promoter. Predicted to act upstream of or within SMAD protein signal transduction. Located in nucleus. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 723.9), Spleen (RPKM 303.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sub1 in Genome Data Viewer
Location:
2q16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62735379..62747545, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61005646..61020486, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62019902..62034704, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene natriuretic peptide receptor 3 Neighboring gene uncharacterized LOC120101085 Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcription reinitiation by RNA polymerase III. Dieci G, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23128323
  2. Molecular cloning and characterization of a cDNA clone for a protein specifically expressed in embryo as well as in a chemically induced pancreatic B cell tumor of rat. Soma G, et al. Biochem Biophys Res Commun, 1984 Oct 15. PMID 6208900
  3. Regulation of pol III transcription by nutrient and stress signaling pathways. Moir RD, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23165150, Free PMC Article
  4. A global transcription cofactor bound to juxtaposed strands of unwound DNA. Werten S, et al. Nat Struct Mol Biol, 2006 Feb. PMID 16415882
  5. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Ge H, et al. Cell, 1994 Aug 12. PMID 8062391

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC109653

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II promoter clearance ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activated RNA polymerase II transcriptional coactivator p15
Names
PC4
RNA polymerase II transcriptional coactivator
SUB1 homolog, transcriptional regulator
p14
pR-ET2 encoded oncodevelopmental protein
positive cofactor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009618.1 → NP_001009618.1  activated RNA polymerase II transcriptional coactivator p15

    See identical proteins and their annotated locations for NP_001009618.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088346
    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A0A8I5ZJM1, A6KJQ6
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    62735379..62747545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232043.5 → XP_006232105.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    See identical proteins and their annotated locations for XP_006232105.1

    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A0A8I5ZJM1, A6KJQ6
    Related
    ENSRNOP00000092370.1
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

  2. XM_063281272.1 → XP_063137342.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A6KJQ6

  3. XM_039101675.2 → XP_038957603.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A0A8I5ZJM1, A6KJQ6
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

  4. XM_039101677.2 → XP_038957605.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A0A8I5ZJM1, A6KJQ6
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)

  5. XM_039101676.2 → XP_038957604.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

    UniProtKB/Swiss-Prot
    Q5M805, Q63396
    UniProtKB/TrEMBL
    A0A8I5ZJM1, A6KJQ6
    Related
    ENSRNOP00000077928.1
    Conserved Domains (1) summary
    pfam02229
    Location:68 → 115
    PC4; Transcriptional Coactivator p15 (PC4)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63396.3 GenPept UniProtKB/Swiss-Prot:Q63396

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