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Slc22a25 solute carrier family 22, member 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192273, updated on 13-Apr-2024

Summary

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Official Symbol
Slc22a25provided by RGD
Official Full Name
solute carrier family 22, member 25provided by RGD
Primary source
RGD:621104
See related
Ensembl:ENSRNOG00000017964 AllianceGenome:RGD:621104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ust1; Ust1r; Slc22a9
Summary
Predicted to enable anion:anion antiporter activity; short-chain fatty acid transmembrane transporter activity; and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in hormone transport; short-chain fatty acid import; and sodium-independent organic anion transport. Predicted to be located in basolateral plasma membrane. Orthologous to several human genes including SLC22A9 (solute carrier family 22 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 783.9) See more
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Genomic context

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Location:
1q43
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (214767837..214956535, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205338698..205498486, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224596886..224698512, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483964 Neighboring gene integral membrane transport protein UST4r Neighboring gene integral membrane transport protein UST5r Neighboring gene enhancer of rudimentary homolog Neighboring gene solute carrier family 22 member 8 Neighboring gene uncharacterized LOC134483966 Neighboring gene solute carrier family 22 member 6 Neighboring gene cholinergic receptor, muscarinic 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct. Yokoyama H, et al. Cell Physiol Biochem, 2008. PMID 18441515
  2. Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Shin HJ, et al. Hepatology, 2007 Apr. PMID 17393504
  3. Molecular cloning and characterization of two novel transport proteins from rat kidney. Schömig E, et al. FEBS Lett, 1998 Mar 20. PMID 9541011
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables short-chain fatty acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables toxin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in hormone transport ISO
Inferred from Sequence Orthology
more info
  
involved_in organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in short-chain fatty acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 24
Names
integral membrane transport UST1r
putative integral membrane transport UST1r
solute carrier family 22 (organic anion/cation transporter), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138908.3 → NP_620263.1  solute carrier family 22 member 24

    See identical proteins and their annotated locations for NP_620263.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    F7ETA0, O70609
    Related
    ENSRNOP00000024234.2, ENSRNOT00000024234.6
    Conserved Domains (3) summary
    cd06174
    Location:125 → 506
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11 → 525
    2A0119; cation transport protein
    cl00214
    Location:39 → 85
    Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    214767837..214956535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093137.2 → XP_038949065.1  solute carrier family 22 member 24 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:1 → 324
    MFS; Major Facilitator Superfamily

RNA

  1. XR_010060855.1 RNA Sequence

  2. XR_010060820.1 RNA Sequence

  3. XR_010060881.1 RNA Sequence

  4. XR_010060788.1 RNA Sequence

  5. XR_010060898.1 RNA Sequence

  6. XR_010060928.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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