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Cdk12 cyclin-dependent kinase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192350, updated on 2-May-2024

Summary

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Official Symbol
Cdk12provided by RGD
Official Full Name
cyclin-dependent kinase 12provided by RGD
Primary source
RGD:621111
See related
Ensembl:ENSRNOG00000006000 AllianceGenome:RGD:621111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hgn; Crk7; Pksc; Crkrs
Summary
Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk12 in Genome Data Viewer
Location:
10q31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83697174..83793676)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (83201177..83256906)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (86157186..86210657)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 20 Neighboring gene mediator complex subunit 1 Neighboring gene neuronal differentiation 2 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma. Wang C, et al. Gut, 2020 Apr. PMID 31519701
  2. Identification of a novel protein for memory regulation in the hippocampus. Zhang XH, et al. Biochem Biophys Res Commun, 2005 Aug 26. PMID 16009348
  3. Low expression of CDK12 in gastric cancer is correlated with advanced stage and poor outcome. Liu M, et al. Pathol Res Pract, 2020 Jul. PMID 32534699
  4. CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Iorns E, et al. Carcinogenesis, 2009 Oct. PMID 19651820
  5. Expression pattern of CDK12 protein in gastric cancer and its positive correlation with CD8(+) cell density and CCL12 expression. Ji J, et al. Int J Med Sci, 2019. PMID 31523177, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK12 and cyclin L1/L2 are cyclin-dependent kinase and cyclin partners and regulate alternative splicing.
    Title: Identification and characterization of the CDK12/cyclin L1 complex involved in alternative splicing regulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cyclin K-CDK12 complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin K-CDK12 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 12
Names
CDC2-related kinase 7
CDC2-related protein kinase 7
Cdc2-related kinase, arginine/serine-rich
cell division cycle 2-related protein kinase 7
cell division protein kinase 12
hippyragranin
protein kinase for splicing component
NP_001029039.1
NP_620271.1
XP_006247312.1
XP_006247313.1
XP_038941089.1
XP_063124451.1
XP_063124452.1
XP_063124453.1
XP_063124454.1
XP_063124455.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033867.2 → NP_001029039.1  cyclin-dependent kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_001029039.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q3MJK5, Q8R458
    Related
    ENSRNOP00000073564.2, ENSRNOT00000082668.2
    Conserved Domains (2) summary
    smart00220
    Location:723 → 1016
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. NM_138916.2 → NP_620271.1  cyclin-dependent kinase 12 isoform 2

    See identical proteins and their annotated locations for NP_620271.1

    Status: VALIDATED

    Source sequence(s)
    AY072294, BE117540
    UniProtKB/TrEMBL
    A6HIQ9
    Related
    ENSRNOP00000092388.1, ENSRNOT00000105342.1
    Conserved Domains (2) summary
    smart00220
    Location:723 → 1016
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83697174..83793676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268383.1 → XP_063124453.1  cyclin-dependent kinase 12 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K5U7

  2. XM_063268381.1 → XP_063124451.1  cyclin-dependent kinase 12 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K5U7

  3. XM_063268382.1 → XP_063124452.1  cyclin-dependent kinase 12 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K5U7

  4. XM_063268384.1 → XP_063124454.1  cyclin-dependent kinase 12 isoform X4

  5. XM_063268385.1 → XP_063124455.1  cyclin-dependent kinase 12 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AHH6

  6. XM_006247251.5 → XP_006247313.1  cyclin-dependent kinase 12 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:723 → 1016
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  7. XM_006247250.5 → XP_006247312.1  cyclin-dependent kinase 12 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q358
    Related
    ENSRNOP00000008256.3
    Conserved Domains (2) summary
    smart00220
    Location:722 → 1015
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:714 → 1015
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  8. XM_039085161.2 → XP_038941089.1  cyclin-dependent kinase 12 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A3V7
    Related
    ENSRNOP00000087177.1
    Conserved Domains (1) summary
    cd07864
    Location:715 → 1016
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MJK5.1 GenPept UniProtKB/Swiss-Prot:Q3MJK5

Gene LinkOut

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