U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Unc50 unc-50 inner nuclear membrane RNA binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 192356, updated on 11-Apr-2024

Summary

Official Symbol
Unc50provided by RGD
Official Full Name
unc-50 inner nuclear membrane RNA binding proteinprovided by RGD
Primary source
RGD:621749
See related
Ensembl:ENSRNOG00000018128 AllianceGenome:RGD:621749
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Uncl
Summary
Enables RNA binding activity. Involved in protein localization to cell surface. Located in nuclear inner membrane. Orthologous to human UNC50 (unc-50 inner nuclear membrane RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 168.9), Lung (RPKM 165.0) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
9q21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47160723..47169710)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39664944..39674369)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44024994..44032896)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene CB1 cannabinoid receptor-interacting protein 1-like Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene uncharacterized LOC120094669 Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Neighboring gene CRACD like Neighboring gene uncharacterized LOC134480567

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein unc-50 homolog
Names
unc-50 homolog
unc-50 related protein (UNCL)
uncoordinated-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138919.3NP_620274.1  protein unc-50 homolog

    See identical proteins and their annotated locations for NP_620274.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    O55227
    UniProtKB/TrEMBL
    A6INH1
    Related
    ENSRNOP00000024582.2, ENSRNOT00000024582.5
    Conserved Domains (1) summary
    pfam05216
    Location:34255
    UNC-50; UNC-50 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    47160723..47169710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244737.5XP_006244799.1  protein unc-50 homolog isoform X1

    See identical proteins and their annotated locations for XP_006244799.1

    UniProtKB/Swiss-Prot
    O55227
    UniProtKB/TrEMBL
    A6INH1
    Conserved Domains (1) summary
    pfam05216
    Location:34255
    UNC-50; UNC-50 family
  2. XM_039083000.2XP_038938928.1  protein unc-50 homolog isoform X2

    Conserved Domains (1) summary
    pfam05216
    Location:34214
    UNC-50; UNC-50 family
  3. XM_006244736.5XP_006244798.1  protein unc-50 homolog isoform X1

    See identical proteins and their annotated locations for XP_006244798.1

    UniProtKB/Swiss-Prot
    O55227
    UniProtKB/TrEMBL
    A6INH1
    Conserved Domains (1) summary
    pfam05216
    Location:34255
    UNC-50; UNC-50 family
  4. XM_063266625.1XP_063122695.1  protein unc-50 homolog isoform X2