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Zc3h14 zinc finger CCCH type containing 14 [ Rattus norvegicus (Norway rat) ]

Gene ID: 192359, updated on 11-Apr-2024

Summary

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Official Symbol
Zc3h14provided by RGD
Official Full Name
zinc finger CCCH type containing 14provided by RGD
Primary source
RGD:621850
See related
Ensembl:ENSRNOG00000004083 AllianceGenome:RGD:621850
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Npuk68
Summary
Predicted to enable poly(A) binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation and regulation of mRNA stability. Located in nuclear speck. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 269.9), Adrenal (RPKM 170.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123736120..123773775)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (118006420..118044480)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122729834..122767462)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene uncharacterized LOC134479245 Neighboring gene EMAP like 5 Neighboring gene tetratricopeptide repeat domain 8 Neighboring gene uncharacterized LOC134479463

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. Leung SW, et al. Gene, 2009 Jun 15. PMID 19303045, Free PMC Article
  2. The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Bienkowski RS, et al. Cell Rep, 2017 Aug 8. PMID 28793261, Free PMC Article
  3. Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Pak C, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21734151, Free PMC Article
  4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105318

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 14
Names
nuclear protein UKp68
nuclear protein UKp83/UKp68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033951.1 → NP_001029123.1  zinc finger CCCH domain-containing protein 14 isoform 1

    See identical proteins and their annotated locations for NP_001029123.1

    Status: PROVISIONAL

    Source sequence(s)
    AB097077
    UniProtKB/Swiss-Prot
    Q7TMD5, Q7TSK6, Q99NC1
    UniProtKB/TrEMBL
    D4A652
    Related
    ENSRNOP00000047580.4, ENSRNOT00000040440.6
    Conserved Domains (1) summary
    pfam14608
    Location:621 → 639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  2. NM_138920.1 → NP_620275.1  zinc finger CCCH domain-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_620275.1

    Status: PROVISIONAL

    Source sequence(s)
    AB032932
    UniProtKB/TrEMBL
    A0A8I6AN22
    Conserved Domains (1) summary
    pfam14608
    Location:551 → 567
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123736120..123773775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764739.4 → XP_008762961.1  zinc finger CCCH domain-containing protein 14 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A1Y3, A0A8I6AN22
    Related
    ENSRNOP00000084418.1
    Conserved Domains (1) summary
    pfam14608
    Location:550 → 566
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  2. XM_039111771.2 → XP_038967699.1  zinc finger CCCH domain-containing protein 14 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AN22

  3. XM_008764738.4 → XP_008762960.1  zinc finger CCCH domain-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    D4A652
    Conserved Domains (1) summary
    pfam14608
    Location:621 → 639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

  4. XM_039111768.2 → XP_038967696.1  zinc finger CCCH domain-containing protein 14 isoform X3

    UniProtKB/TrEMBL
    D4A652

  5. XM_039111767.2 → XP_038967695.1  zinc finger CCCH domain-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    D4A7G0
    Related
    ENSRNOP00000035319.6

  6. XM_039111772.2 → XP_038967700.1  zinc finger CCCH domain-containing protein 14 isoform X6

    Conserved Domains (1) summary
    COG1196
    Location:35 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_008764740.3 → XP_008762962.1  zinc finger CCCH domain-containing protein 14 isoform X8

    UniProtKB/TrEMBL
    A0A0G2K596
    Related
    ENSRNOP00000073344.1
    Conserved Domains (2) summary
    COG1196
    Location:35 → 145
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    COG5084
    Location:179 → 273
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]

  8. XM_063261539.1 → XP_063117609.1  zinc finger CCCH domain-containing protein 14 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMD5.1 GenPept UniProtKB/Swiss-Prot:Q7TMD5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
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