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Ptn pleiotrophin [ Mus musculus (house mouse) ]

Gene ID: 19242, updated on 13-Jan-2025

Summary

Official Symbol
Ptnprovided by MGI
Official Full Name
pleiotrophinprovided by MGI
Primary source
MGI:MGI:97804
See related
Ensembl:ENSMUSG00000029838 AllianceGenome:MGI:97804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OSF; HARP; HBBM; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8
Summary
Predicted to enable several functions, including glycosaminoglycan binding activity; signaling receptor binding activity; and syndecan binding activity. Involved in several processes, including decidualization; learning or memory; and regulation of nervous system development. Acts upstream of or within bone mineralization. Located in extracellular region. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in CNS E18 (RPKM 106.8), frontal lobe adult (RPKM 95.9) and 7 other tissues See more
Orthologs
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Genomic context

See Ptn in Genome Data Viewer
Location:
6 B1; 6 15.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (36691863..36787114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (36714924..36810179, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15570 Neighboring gene predicted gene, 53281 Neighboring gene STARR-seq mESC enhancer starr_15571 Neighboring gene predicted gene 2189 Neighboring gene STARR-seq mESC enhancer starr_15572 Neighboring gene predicted gene, 53282 Neighboring gene STARR-seq mESC enhancer starr_15573 Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted gene, 52857 Neighboring gene predicted pseudogene 7452

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding  
enables chondroitin sulfate binding  
enables chondroitin sulfate binding  
enables chondroitin sulfate proteoglycan binding  
enables glycosaminoglycan binding  
enables growth factor activity  
enables growth factor activity  
enables growth factor activity  
enables heparan sulfate binding  
enables heparin binding  
enables heparin binding  
enables integrin binding  
enables integrin binding  
enables molecular function activator activity  
enables protein kinase binding  
enables protein kinase binding  
enables protein phosphatase inhibitor activity  
enables protein phosphatase inhibitor activity  
enables proteoglycan binding  
enables syndecan binding  
enables vascular endothelial growth factor binding  
Items 1 - 25 of 59
Process Evidence Code Pubs
acts_upstream_of_or_within bone mineralization PubMed 
involved_in decidualization PubMed 
involved_in dendrite arborization PubMed 
involved_in dendrite regeneration  
involved_in dendrite regeneration  
involved_in estrous cycle PubMed 
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
acts_upstream_of_or_within learning PubMed 
involved_in learning PubMed 
involved_in leukocyte chemotaxis involved in inflammatory response PubMed 
involved_in memory PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in negative regulation of angiogenesis  
involved_in negative regulation of cell migration  
involved_in negative regulation of epithelial cell proliferation  
involved_in negative regulation of glial cell proliferation  
involved_in negative regulation of long-term synaptic potentiation PubMed 
involved_in negative regulation of membrane potential  
involved_in negative regulation of mesenchymal cell proliferation  
involved_in negative regulation of neuroblast proliferation PubMed 
involved_in negative regulation of neuromuscular junction development  
involved_in oogenesis PubMed 
acts_upstream_of_or_within ossification PubMed 
involved_in ossification involved in bone remodeling  
involved_in ossification involved in bone remodeling  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of axon regeneration  
involved_in positive regulation of axon regeneration  
involved_in positive regulation of bone mineralization PubMed 
involved_in positive regulation of cell differentiation PubMed 
involved_in positive regulation of cell division  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell-substrate adhesion  
involved_in positive regulation of dendrite development PubMed 
involved_in positive regulation of hepatocyte proliferation PubMed 
involved_in positive regulation of hepatocyte proliferation  
involved_in positive regulation of leukocyte chemotaxis PubMed 
involved_in positive regulation of neuron projection development  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of oligodendrocyte differentiation  
involved_in positive regulation of oligodendrocyte differentiation  
involved_in positive regulation of ossification  
involved_in positive regulation of ossification  
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering  
involved_in positive regulation of stem cell differentiation PubMed 
involved_in receptor clustering  
involved_in receptor clustering  
involved_in regulation of cell shape  
involved_in regulation of endothelial cell migration  
involved_in regulation of hemopoiesis PubMed 
involved_in regulation of myelination PubMed 
involved_in regulation of stem cell population maintenance PubMed 
involved_in regulation of synaptic plasticity PubMed 
involved_in response to auditory stimulus PubMed 
involved_in retinal rod cell differentiation  
involved_in tissue regeneration PubMed 
Items 1 - 25 of 59
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse PubMed 
is_active_in Schaffer collateral - CA1 synapse PubMed 
located_in basement membrane  
located_in cell surface  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in extracellular matrix PubMed 
is_active_in extracellular region  
located_in extracellular region PubMed 
located_in extracellular region  
located_in extracellular space  
located_in extracellular space  
located_in neuromuscular junction  
located_in perinuclear region of cytoplasm  
located_in plasma membrane  
is_active_in postsynapse  
is_active_in presynapse  
part_of protein-containing complex  
part_of protein-containing complex  

General protein information

Preferred Names
pleiotrophin
Names
heparin-binding brain mitogen
heparin-binding growth factor 8
heparin-binding growth-associated molecule
heparin-binding neutrophic factor
osteoblast-specific factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410273.1NP_001397202.1  pleiotrophin precursor

    Status: VALIDATED

    Source sequence(s)
    AC153902, AC154019
    UniProtKB/Swiss-Prot
    P20935, P63089
    UniProtKB/TrEMBL
    Q9CSX6
  2. NM_008973.3NP_032999.1  pleiotrophin precursor

    See identical proteins and their annotated locations for NP_032999.1

    Status: VALIDATED

    Source sequence(s)
    AI838962, AK011346, AK011699
    Consensus CDS
    CCDS20005.1
    UniProtKB/Swiss-Prot
    P20935, P63089
    UniProtKB/TrEMBL
    Q9CSX6
    Related
    ENSMUSP00000099073.2, ENSMUST00000101534.5
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    36691863..36787114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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