Ptprcap protein tyrosine phosphatase receptor type C polypeptide-associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprcapprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type C polypeptide-associated proteinprovided by MGI
Primary source: MGI:MGI:97811
See related: Ensembl:ENSMUSG00000045826 AllianceGenome:MGI:97811
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LPAP; LSM-1; CD-45-AP
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in bone marrow; embryo; spleen; thymus; and thymus primordium. Orthologous to human PTPRCAP (protein tyrosine phosphatase receptor type C associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in thymus adult (RPKM 458.8), spleen adult (RPKM 332.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 3.86 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4204645..4206709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4154646..4156710)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results support a model in which binding of CD45-AP to inactive CD45 dimers converts them to active monomers
Title: CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity.
The association of LPAP with CD45 is dispensable for CD45-mediated apoptosis signaling, as shown in studies of LPAP knocked-out thymocytes.
Title: Apoptosis mediated through CD45 is independent of its phosphatase activity and association with leukocyte phosphatase-associated phosphoprotein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein tyrosine phosphatase receptor type C-associated protein

Names: CD45-AP; CD45-associated protein; PTPRC-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.