Trpv1 transient receptor potential cation channel, subfamily V, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpv1provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily V, member 1provided by MGI
Primary source: MGI:MGI:1341787
See related: Ensembl:ENSMUSG00000005952 AllianceGenome:MGI:1341787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vr1; VR-1; OTRPC1; TRPV1beta; TRPV1alpha
Summary: Enables calcium channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain; ion transmembrane transport; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including detection of stimulus involved in sensory perception; diet induced thermogenesis; and fever generation. Located in neuron projection and plasma membrane. Is expressed in central nervous system; cochlea; and dorsal root ganglion. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 1.7), subcutaneous fat pad adult (RPKM 1.4) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B4; 11 45.25 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (73124975..73152148)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (73234149..73261322)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient Receptor Potential Vanilloid-1 Channels Facilitate Axonal Degeneration of Corneal Sensory Nerves in Dry Eye.
Title: Transient Receptor Potential Vanilloid-1 Channels Facilitate Axonal Degeneration of Corneal Sensory Nerves in Dry Eye.
Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord.
Title: Lysophosphatidic acid contributes to myocardial ischemia/reperfusion injury by activating TRPV1 in spinal cord.
Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model.
Title: Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model.
Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement.
Title: Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement.
Expression of the Transient Receptor Potential Vanilloid 1 ion channel in the supramammillary nucleus and the antidepressant effects of its antagonist AMG9810 in mice.
Title: Expression of the Transient Receptor Potential Vanilloid 1 ion channel in the supramammillary nucleus and the antidepressant effects of its antagonist AMG9810 in mice.
TRPV1 modulated NLRP3 inflammasome activation via calcium in experimental subarachnoid hemorrhage.
Title: TRPV1 modulated NLRP3 inflammasome activation via calcium in experimental subarachnoid hemorrhage.
Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.
Title: Early in life stressful events induce chronic visceral pain and changes in bladder function in adult female mice through a mechanism involving TRPV1 and alpha 1A adrenoceptors.
Activation of Transient Receptor Potential Vanilloid 1 Is Involved in Both Pain and Tumor Growth in a Mouse Model of Cancer Pain.
Title: Activation of Transient Receptor Potential Vanilloid 1 Is Involved in Both Pain and Tumor Growth in a Mouse Model of Cancer Pain.
TRPV1 controls innate immunity during Citrobacter rodentium enteric infection.
Title: TRPV1 controls innate immunity during Citrobacter rodentium enteric infection.
Activation of TRPV1 Channels Inhibits the Release of Acetylcholine and Improves Muscle Contractility in Mice.
Title: Activation of TRPV1 Channels Inhibits the Release of Acetylcholine and Improves Muscle Contractility in Mice.

Submit: New GeneRIF Correction See all GeneRIFs (556)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (11) 1 citation
Spontaneous (1) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpv1 (e-PCR), detects polymorphism
- UniSTS:531254

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables chloride channel regulator activity	ISO Inferred from Sequence Orthology more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables extracellular ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	ISA Inferred from Sequence Alignment more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables temperature-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables temperature-gated ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within behavioral response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within catagen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to ATP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkaloid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within diet induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutamate secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	ISA Inferred from Sequence Alignment more info	PubMed
involved_in monoatomic ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of establishment of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in response to capsazepine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organonitrogen compound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle contraction involved in micturition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thermoception	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 1

Names: capsaicin receptor; cation channel; deltaN-TRPv1; osm-9-like TRP channel 1; transient receptor potential cation channel V1; vanilloid receptor 1; vanilloid receptor subtype 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001445.2 → NP_001001445.1 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_001001445.1

Status: VALIDATED

Source sequence(s)

AK051315, AL663116

Consensus CDS

CCDS25003.1

UniProtKB/Swiss-Prot

Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0, Q704Y3

UniProtKB/TrEMBL

Q3V318

Related

ENSMUSP00000099585.3, ENSMUST00000102526.9

Conserved Domains (3) summary

cd00204
Location:200 → 354

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:52 → 825

trp; transient-receptor-potential calcium channel protein

sd00045
Location:202 → 232

ANK; ANK repeat [structural motif]