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Rad17 RAD17 checkpoint clamp loader component [ Mus musculus (house mouse) ]

Gene ID: 19356, updated on 28-Apr-2024

Summary

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Official Symbol
Rad17provided by MGI
Official Full Name
RAD17 checkpoint clamp loader componentprovided by MGI
Primary source
MGI:MGI:1333807
See related
Ensembl:ENSMUSG00000021635 AllianceGenome:MGI:1333807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MmRad24
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of Rad17 RFC-like complex. Predicted to colocalize with chromosome, telomeric region. Is expressed in embryo. Orthologous to human RAD17 (RAD17 checkpoint clamp loader component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.8), CNS E11.5 (RPKM 6.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 53.23 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100753672..100787569, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100617164..100651061, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene Neighboring gene MARVEL (membrane-associating) domain containing 2 Neighboring gene predicted gene, 24261 Neighboring gene STARR-positive B cell enhancer ABC_E7268 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene coiled-coil domain containing 125 Neighboring gene cyclin dependent kinase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. Budzowska M, et al. EMBO J, 2004 Sep 1. PMID 15297881, Free PMC Article
  2. Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage. Post S, et al. Proc Natl Acad Sci U S A, 2001 Nov 6. PMID 11687627, Free PMC Article
  3. HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma. Bao S, et al. Cancer Res, 1999 May 1. PMID 10232579
  4. Human and mouse homologs of the Schizosaccharomyces pombe rad17+ cell cycle checkpoint control gene. Bluyssen HA, et al. Genomics, 1999 Jan 15. PMID 9933569
  5. The mammalian Rad24 homologous to yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 is involved in DNA damage checkpoint. Bao S, et al. Cell Growth Differ, 1998 Dec. PMID 9869296

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 9430035O09Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin-protein adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic intra-S DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rad17 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell cycle checkpoint protein RAD17
Names
RAD17 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044371.2 → NP_001037836.1  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_001037836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC165159, AK134277, BC066855, BY129390
    Consensus CDS
    CCDS26733.1
    UniProtKB/Swiss-Prot
    O88934, O89024, Q6NXW6
    UniProtKB/TrEMBL
    Q3UYY2
    Related
    ENSMUSP00000136292.2, ENSMUST00000177848.3
    Conserved Domains (1) summary
    TIGR00602
    Location:13 → 653
    rad24; checkpoint protein rad24

  2. NM_001283011.1 → NP_001269940.1  cell cycle checkpoint protein RAD17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC165159, AK134277, AK167358, BC066855, BY129390
    UniProtKB/Swiss-Prot
    Q6NXW6
    UniProtKB/TrEMBL
    Q3UYY2
    Conserved Domains (1) summary
    TIGR00602
    Location:1 → 444
    rad24; checkpoint protein rad24

  3. NM_011233.3 → NP_035363.2  cell cycle checkpoint protein RAD17 isoform 1

    See identical proteins and their annotated locations for NP_035363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC165159, AK134277, BC066855, BY129390, CF916039
    Consensus CDS
    CCDS26733.1
    UniProtKB/Swiss-Prot
    O88934, O89024, Q6NXW6
    UniProtKB/TrEMBL
    Q3UYY2
    Related
    ENSMUSP00000022136.7, ENSMUST00000022136.14
    Conserved Domains (1) summary
    TIGR00602
    Location:13 → 653
    rad24; checkpoint protein rad24

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100753672..100787569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157920.1 → XP_036013813.1  cell cycle checkpoint protein RAD17 isoform X1

    UniProtKB/Swiss-Prot
    O88934, O89024, Q6NXW6
    UniProtKB/TrEMBL
    Q3UYY2
    Conserved Domains (1) summary
    TIGR00602
    Location:13 → 653
    rad24; checkpoint protein rad24
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NXW6.2 GenPept UniProtKB/Swiss-Prot:Q6NXW6

Gene LinkOut

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