Replication interactions
Interaction |
Pubs |
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of EEF2 |
PubMed
|
SiRNA-mediated depletion of EEF2 protein inhibits HIV-1 replication and infectivity in human cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Pr55(Gag)
|
gag
|
Treatment of cells with cyclosporine A blocks the interaction of HIV-1 Gag with eEF2, indicating that cyclophilin A (CypA) stabilizes the Gag-eEF2 association |
PubMed
|
|
gag
|
The CA N-terminal domain of HIV-1 Gag mediates eEF2 binding in cells |
PubMed
|
|
gag
|
Overexpression of G3BP1 inhibits the interaction between HIV-1 Gag and eEF2 in cells, suggesting that G3BP1 competes with eEF2 binding to Gag |
PubMed
|
|
gag
|
SiRNA-mediated depletion of eEF2 protein modulates HIV-1 production by measurement of HIV-Gag in virions |
PubMed
|
|
gag
|
HIV-1 Gag interacts with eEF2 to block stress granule (SG) assembly and siRNA-mediated depletion of eEF2 fails to inhibit SG assembly |
PubMed
|
Vpr
|
vpr
|
Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr |
PubMed
|
retropepsin
|
gag-pol
|
Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 2 (EEF2) at amino acid residues 395-396 by the HIV-1 protease |
PubMed
|
Go to the HIV-1, Human Interaction Database