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ELAVL1 ELAV like RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1994, updated on 5-Jan-2025

Summary

Official Symbol
ELAVL1provided by HGNC
Official Full Name
ELAV like RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:3312
See related
Ensembl:ENSG00000066044 MIM:603466; AllianceGenome:HGNC:3312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUR; Hua; MelG; ELAV1
Summary
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in testis (RPKM 14.6), brain (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See ELAVL1 in Genome Data Viewer
Location:
19p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7958573..8005641, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7959562..8006636, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8023457..8070525, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10003 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:7991701-7992450 Neighboring gene Sharpr-MPRA regulatory region 3551 Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8007572-8008115 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8008116-8008658 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8008659-8009202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:8009203-8009745 Neighboring gene MPRA-validated peak3325 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8033572-8034184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8034185-8034798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:8042669-8043169 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8066604-8067215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8067216-8067826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10008 Neighboring gene uncharacterized LOC105372266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:8094053-8095028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10009 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10010 Neighboring gene C-C motif chemokine ligand 25

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ELAV-like 1 protein (ELAVL1; Hu antigen R, HUR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
nucleocapsid gag HIV-1 NC upregulates ELAVL1 (embryonic lethal, abnormal vision, Drosophila)-like 1 in HEK 293T cells PubMed
reverse transcriptase gag-pol No direct protein-protein interaction between purified full-length HuR and HIV-1 RT is detected using NMR titrations PubMed
gag-pol HIV-1 RT heterodimer (p66/p51) interacts directly with HuR PubMed
gag-pol HuR interacts with HIV-1 p66 reverse transcriptase. Amino acids 286-326 in the third RNA recognition domain of HuR and amino acids 482-539 in the RNase H domain of p66 RT are required for their interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding PubMed 
enables RNA binding PubMed 
enables double-stranded RNA binding PubMed 
enables lncRNA binding  
enables mRNA 3'-UTR AU-rich region binding PubMed 
enables mRNA 3'-UTR binding PubMed 
enables mRNA 3'-UTR binding  
enables mRNA binding PubMed 
enables miRNA binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
enables protein kinase binding PubMed 
Component Evidence Code Pubs
located_in P-body  
located_in cytoplasm PubMed 
located_in cytoplasmic stress granule  
located_in cytoplasmic vesicle  
located_in cytosol PubMed 
located_in cytosol  
located_in endoplasmic reticulum  
located_in glutamatergic synapse  
located_in membrane PubMed 
located_in nucleoplasm PubMed 
located_in nucleoplasm  
located_in nucleus PubMed 
located_in postsynapse  
part_of ribonucleoprotein complex  
located_in sarcoplasm  

General protein information

Preferred Names
ELAV-like protein 1
Names
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Hu antigen R
Human antigen R
embryonic lethal, abnormal vision, drosophila, homolog-like 1
hu-antigen R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419.3NP_001410.2  ELAV-like protein 1

    See identical proteins and their annotated locations for NP_001410.2

    Status: REVIEWED

    Source sequence(s)
    AI375368, AL713686, AW139417, BC003376, BM664469, BM696191, BU542524, W37464
    Consensus CDS
    CCDS12193.1
    UniProtKB/Swiss-Prot
    B4DVB8, Q15717, Q53XN6, Q9BTT1
    Related
    ENSP00000385269.1, ENST00000407627.7
    Conserved Domains (1) summary
    TIGR01661
    Location:19326
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    7958573..8005641 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438384.1XP_047294340.1  ELAV-like protein 1 isoform X2

    UniProtKB/TrEMBL
    M0QZR9
  2. XM_047438383.1XP_047294339.1  ELAV-like protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    7959562..8006636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320149.1XP_054176124.1  ELAV-like protein 1 isoform X2

    UniProtKB/TrEMBL
    M0QZR9
  2. XM_054320148.1XP_054176123.1  ELAV-like protein 1 isoform X1

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