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Scn1b sodium channel, voltage-gated, type I, beta [ Mus musculus (house mouse) ]

Gene ID: 20266, updated on 4-Jan-2025

Summary

Official Symbol
Scn1bprovided by MGI
Official Full Name
sodium channel, voltage-gated, type I, betaprovided by MGI
Primary source
MGI:MGI:98247
See related
Ensembl:ENSMUSG00000019194 AllianceGenome:MGI:98247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables sodium channel inhibitor activity. Involved in several processes, including membrane depolarization during cardiac muscle cell action potential; regulation of sodium ion transport; and regulation of ventricular cardiac muscle cell membrane repolarization. Acts upstream of or within several processes, including corticospinal neuron axon guidance; neuronal action potential propagation; and positive regulation of neuron projection development. Located in T-tubule; intercalated disc; and node of Ranvier. Part of voltage-gated sodium channel complex. Is expressed in heart and telencephalon. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; developmental and epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus 1. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in cerebellum adult (RPKM 317.2), cortex adult (RPKM 267.6) and 9 other tissues See more
Orthologs
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Genomic context

See Scn1b in Genome Data Viewer
Location:
7 B1; 7 19.3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30815949..30826436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (31116524..31127023, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 3 Neighboring gene predicted gene, 53358 Neighboring gene STARR-positive B cell enhancer mm9_chr7:31896031-31896332 Neighboring gene hepsin Neighboring gene GRAM domain containing 1A Neighboring gene STARR-seq mESC enhancer starr_18545 Neighboring gene STARR-seq mESC enhancer starr_18546 Neighboring gene predicted gene 10640

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 32
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance PubMed 
involved_in cardiac conduction PubMed 
involved_in cardiac muscle cell action potential involved in contraction  
involved_in cardiac muscle cell action potential involved in contraction  
involved_in cardiac muscle cell action potential involved in contraction  
involved_in cardiac muscle contraction  
acts_upstream_of_or_within corticospinal neuron axon guidance PubMed 
acts_upstream_of_or_within locomotion PubMed 
involved_in membrane depolarization  
involved_in membrane depolarization during Purkinje myocyte cell action potential  
involved_in membrane depolarization during Purkinje myocyte cell action potential  
involved_in membrane depolarization during cardiac muscle cell action potential  
involved_in membrane depolarization during cardiac muscle cell action potential PubMed 
acts_upstream_of neuron projection development PubMed 
acts_upstream_of_or_within neuronal action potential propagation PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development PubMed 
involved_in positive regulation of sodium ion transport  
involved_in positive regulation of voltage-gated sodium channel activity  
involved_in positive regulation of voltage-gated sodium channel activity  
involved_in regulation of atrial cardiac muscle cell membrane depolarization  
involved_in regulation of atrial cardiac muscle cell membrane depolarization  
involved_in regulation of heart rate by cardiac conduction  
involved_in regulation of heart rate by cardiac conduction  
involved_in regulation of heart rate by cardiac conduction  
involved_in regulation of sodium ion transmembrane transporter activity  
involved_in regulation of sodium ion transport PubMed 
involved_in regulation of sodium ion transport  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization PubMed 
involved_in response to pyrethroid  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transmembrane transport  
involved_in sodium ion transmembrane transport  
Items 1 - 25 of 32
Component Evidence Code Pubs
located_in T-tubule PubMed 
located_in intercalated disc PubMed 
located_in node of Ranvier PubMed 
located_in node of Ranvier  
located_in perikaryon  
located_in plasma membrane  
located_in plasma membrane  
part_of sodium channel complex PubMed 
part_of voltage-gated sodium channel complex  
part_of voltage-gated sodium channel complex PubMed 
part_of voltage-gated sodium channel complex  
part_of voltage-gated sodium channel complex  

General protein information

Preferred Names
sodium channel regulatory subunit beta-1
Names
sodium channel subunit beta-1
sodium channel, voltage-gated, type I, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402334.1NP_001389263.1  sodium channel regulatory subunit beta-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158993
    Conserved Domains (2) summary
    cd00096
    Location:2225
    Ig; Ig strand C [structural motif]
    pfam07686
    Location:8114
    V-set; Immunoglobulin V-set domain
  2. NM_011322.4NP_035452.1  sodium channel regulatory subunit beta-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_035452.1

    Status: VALIDATED

    Source sequence(s)
    AC158993
    Consensus CDS
    CCDS21126.1
    UniProtKB/Swiss-Prot
    P97952
    Related
    ENSMUSP00000096148.5, ENSMUST00000098548.8
    Conserved Domains (1) summary
    pfam07686
    Location:23147
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    30815949..30826436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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