U.S. flag

An official website of the United States government

Selp selectin, platelet [ Mus musculus (house mouse) ]

Gene ID: 20344, updated on 4-Jan-2025

Summary

Official Symbol
Selpprovided by MGI
Official Full Name
selectin, plateletprovided by MGI
Primary source
MGI:MGI:98280
See related
Ensembl:ENSMUSG00000026580 AllianceGenome:MGI:98280
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grmp; CD62P; LECAM3; PADGEM; GMP-140
Summary
Enables calcium-dependent protein binding activity and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling and positive regulation of platelet activation. Acts upstream of or within several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte tethering or rolling; and positive regulation of leukocyte migration. Located in external side of plasma membrane. Is expressed in blood and liver. Human ortholog(s) of this gene implicated in atopic dermatitis and myocardial infarction. Orthologous to human SELP (selectin P). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 2.1), bladder adult (RPKM 1.8) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Selp in Genome Data Viewer
Location:
1 H2.2; 1 71.42 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163942833..163977595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164115264..164150026)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02864 Neighboring gene selectin, endothelial cell Neighboring gene STARR-positive B cell enhancer ABC_E7768 Neighboring gene STARR-positive B cell enhancer ABC_E3322 Neighboring gene STARR-positive B cell enhancer ABC_E10052 Neighboring gene STARR-positive B cell enhancer ABC_E7769 Neighboring gene STARR-positive B cell enhancer ABC_E11099 Neighboring gene STARR-positive B cell enhancer ABC_E11100 Neighboring gene STARR-positive B cell enhancer ABC_E9063 Neighboring gene selectin, lymphocyte Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:166065744-166065853 Neighboring gene STARR-positive B cell enhancer ABC_E2579 Neighboring gene STARR-positive B cell enhancer ABC_E4370 Neighboring gene predicted gene 16548 Neighboring gene coagulation factor V Neighboring gene STARR-positive B cell enhancer ABC_E4371 Neighboring gene microRNA 12178 Neighboring gene STARR-seq mESC enhancer starr_02865 Neighboring gene STARR-seq mESC enhancer starr_02866 Neighboring gene solute carrier family 19 (thiamine transporter), member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Clone Names

  • MGC129336, MGC129337

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding  
enables calcium-dependent protein binding PubMed 
enables fucose binding  
enables fucose binding  
enables heparin binding  
enables heparin binding  
enables integrin binding  
enables integrin binding  
enables lipopolysaccharide binding  
enables lipopolysaccharide binding  
enables oligosaccharide binding  
enables oligosaccharide binding  
enables oligosaccharide binding  
enables protein binding PubMed 
enables sialic acid binding  
enables sialic acid binding PubMed 
enables sialic acid binding  
Items 1 - 25 of 29
Process Evidence Code Pubs
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
involved_in cell-cell adhesion  
involved_in cell-cell adhesion  
acts_upstream_of_or_within cellular response to interleukin-6 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules  
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
acts_upstream_of_or_within inflammatory response PubMed 
acts_upstream_of_or_within leukocyte cell-cell adhesion PubMed 
involved_in leukocyte cell-cell adhesion  
acts_upstream_of leukocyte migration PubMed 
acts_upstream_of leukocyte migration PubMed 
acts_upstream_of_or_within leukocyte migration PubMed 
involved_in leukocyte migration  
involved_in leukocyte tethering or rolling  
acts_upstream_of_or_within leukocyte tethering or rolling PubMed 
involved_in leukocyte tethering or rolling  
involved_in leukocyte tethering or rolling  
involved_in positive regulation of cell adhesion  
acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
involved_in positive regulation of leukocyte tethering or rolling PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of platelet activation PubMed 
involved_in regulation of cellular extravasation  
involved_in regulation of integrin activation  
involved_in regulation of integrin activation  
involved_in response to cytokine  
Items 1 - 25 of 29
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in external side of plasma membrane  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in platelet alpha granule membrane  

General protein information

Preferred Names
P-selectin
Names
CD62 antigen-like family member P
granule membrane protein 140
leukocyte-endothelial cell adhesion molecule 3
platelet activation dependent granule-external membrane protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011347.2NP_035477.1  P-selectin precursor

    See identical proteins and their annotated locations for NP_035477.1

    Status: VALIDATED

    Source sequence(s)
    AC110499, BC109159
    Consensus CDS
    CCDS48422.1
    UniProtKB/Swiss-Prot
    Q01102, Q32MF1
    Related
    ENSMUSP00000123924.2, ENSMUST00000162746.2
    Conserved Domains (3) summary
    cd00033
    Location:324382
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:42160
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:168195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163942833..163977595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.