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Shh sonic hedgehog [ Mus musculus (house mouse) ]

Gene ID: 20423, updated on 14-Jan-2025

Summary

Official Symbol
Shhprovided by MGI
Official Full Name
sonic hedgehogprovided by MGI
Primary source
MGI:MGI:98297
See related
Ensembl:ENSMUSG00000002633 AllianceGenome:MGI:98297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hx; Dsh; Hhg1; Hxl3; HHG-1; ShhNC; M100081; 9530036O11Rik
Summary
Enables several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hemopoiesis; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including nervous system development; respiratory system development; and tube morphogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study brachydactyly type A1; holoprosencephaly 3; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly (multiple). Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in bladder adult (RPKM 27.9), adrenal adult (RPKM 21.2) and 9 other tissues See more
Orthologs
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Genomic context

See Shh in Genome Data Viewer
Location:
5 B1; 5 14.39 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (28661838..28672099, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (28456840..28467101, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12716 Neighboring gene predicted gene, 35524 Neighboring gene predicted gene, 35602 Neighboring gene RNA binding motif protein 33 Neighboring gene STARR-seq mESC enhancer starr_12719 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:28729422-28729605 Neighboring gene STARR-seq mESC enhancer starr_12720 Neighboring gene STARR-seq mESC enhancer starr_12721 Neighboring gene RIKEN cDNA 9530036O11Rik Neighboring gene sonic hedgehog brain enhancer region in intron 2 Neighboring gene sonic hedgehog floor plate enhancer 1 Neighboring gene STARR-seq mESC enhancer starr_12722 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_12723 Neighboring gene Shh lung-gut enhancer Neighboring gene STARR-seq mESC enhancer starr_12725 Neighboring gene predicted gene, 52839

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (5) 
  • Radiation induced (1) 
  • Targeted (21)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding  
enables calcium ion binding  
enables calcium ion binding  
enables cholesterol-protein transferase activity PubMed 
enables glycosaminoglycan binding PubMed 
NOT enables hydrolase activity PubMed 
enables laminin-1 binding PubMed 
enables patched binding  
enables patched binding PubMed 
enables patched binding  
enables peptidase activity PubMed 
enables protein binding PubMed 
enables zinc ion binding  
enables zinc ion binding  
Items 1 - 25 of 294
Process Evidence Code Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation PubMed 
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment PubMed 
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  
acts_upstream_of T cell differentiation in thymus PubMed 
involved_in T cell differentiation in thymus PubMed 
acts_upstream_of T cell proliferation PubMed 
acts_upstream_of alpha-beta T cell differentiation PubMed 
involved_in alpha-tubulin acetylation PubMed 
acts_upstream_of_or_within anatomical structure development PubMed 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis PubMed 
acts_upstream_of_or_within androgen metabolic process PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within animal organ formation PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
involved_in apoptotic signaling pathway PubMed 
acts_upstream_of_or_within artery development PubMed 
acts_upstream_of_or_within artery development PubMed 
acts_upstream_of astrocyte differentiation PubMed 
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within blood coagulation PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis PubMed 
acts_upstream_of_or_within branching involved in prostate gland morphogenesis PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube PubMed 
acts_upstream_of_or_within bud outgrowth involved in lung branching PubMed 
acts_upstream_of_or_within camera-type eye development PubMed 
acts_upstream_of_or_within camera-type eye development PubMed 
acts_upstream_of_or_within camera-type eye development PubMed 
acts_upstream_of canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within cell development PubMed 
acts_upstream_of_or_within cell fate commitment PubMed 
involved_in cell fate specification  
acts_upstream_of_or_within cell fate specification PubMed 
acts_upstream_of_or_within cell fate specification PubMed 
acts_upstream_of_or_within cell fate specification PubMed 
acts_upstream_of cell migration PubMed 
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within cell population proliferation PubMed 
acts_upstream_of cell population proliferation PubMed 
acts_upstream_of_or_within cell proliferation in external granule layer PubMed 
acts_upstream_of_or_within cell-cell signaling PubMed 
acts_upstream_of_or_within cellular response to lithium ion PubMed 
acts_upstream_of_or_within central nervous system development PubMed 
acts_upstream_of cerebellar granule cell precursor proliferation PubMed 
involved_in cerebellar granule cell precursor proliferation PubMed 
involved_in cerebellar granule cell precursor proliferation PubMed 
involved_in commissural neuron axon guidance  
involved_in determination of left/right asymmetry in lateral mesoderm PubMed 
acts_upstream_of_or_within determination of left/right symmetry PubMed 
acts_upstream_of_or_within developmental growth PubMed 
involved_in digestive tract mesoderm development  
acts_upstream_of_or_within digestive tract morphogenesis PubMed 
involved_in dopaminergic neuron differentiation PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
acts_upstream_of_or_within dorsal/ventral neural tube patterning PubMed 
involved_in dorsal/ventral neural tube patterning PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
acts_upstream_of_or_within ectoderm development PubMed 
acts_upstream_of_or_within embryo development PubMed 
acts_upstream_of_or_within embryo development PubMed 
acts_upstream_of_or_within embryonic digestive tract morphogenesis PubMed 
involved_in embryonic digestive tract morphogenesis PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis PubMed 
involved_in embryonic digit morphogenesis PubMed 
acts_upstream_of_or_within embryonic foregut morphogenesis PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis PubMed 
acts_upstream_of_or_within embryonic hindlimb morphogenesis PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
acts_upstream_of_or_within embryonic morphogenesis PubMed 
acts_upstream_of_or_within embryonic organ development PubMed 
acts_upstream_of_or_within embryonic skeletal system development PubMed 
acts_upstream_of_or_within endocytosis PubMed 
acts_upstream_of epithelial cell proliferation PubMed 
acts_upstream_of epithelial cell proliferation PubMed 
acts_upstream_of epithelial cell proliferation involved in prostate gland development PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis PubMed 
acts_upstream_of_or_within epithelial-mesenchymal cell signaling PubMed 
acts_upstream_of_or_within epithelial-mesenchymal signaling involved in prostate gland development PubMed 
acts_upstream_of_or_within establishment of epithelial cell polarity PubMed 
acts_upstream_of_or_within forebrain development PubMed 
acts_upstream_of_or_within forebrain regionalization PubMed 
acts_upstream_of_or_within formation of anatomical boundary PubMed 
involved_in fungiform papilla development  
involved_in fungiform papilla formation  
involved_in fungiform papilla morphogenesis  
acts_upstream_of_or_within gene expression PubMed 
acts_upstream_of_or_within gene expression PubMed 
involved_in gene expression PubMed 
acts_upstream_of_or_within hair follicle development PubMed 
acts_upstream_of_or_within hair follicle morphogenesis PubMed 
acts_upstream_of_or_within heart development PubMed 
acts_upstream_of_or_within heart looping PubMed 
involved_in heart looping PubMed 
acts_upstream_of_or_within hindbrain development PubMed 
acts_upstream_of_or_within hindbrain development PubMed 
acts_upstream_of_or_within hindgut morphogenesis PubMed 
acts_upstream_of_or_within inner ear development PubMed 
acts_upstream_of_or_within inner ear development PubMed 
involved_in intein-mediated protein splicing  
acts_upstream_of_or_within intermediate filament organization PubMed 
acts_upstream_of_or_within kidney development PubMed 
acts_upstream_of_or_within left lung development PubMed 
acts_upstream_of_or_within limb bud formation PubMed 
acts_upstream_of_or_within limb development PubMed 
acts_upstream_of_or_within limb development PubMed 
acts_upstream_of_or_within lung development PubMed 
acts_upstream_of_or_within lung development PubMed 
acts_upstream_of_or_within lung epithelium development PubMed 
acts_upstream_of_or_within lung lobe morphogenesis PubMed 
acts_upstream_of_or_within lung morphogenesis PubMed 
acts_upstream_of_or_within lung-associated mesenchyme development PubMed 
involved_in lymphoid progenitor cell differentiation PubMed 
involved_in lymphoid progenitor cell differentiation  
acts_upstream_of_or_within male genitalia development PubMed 
involved_in male genitalia morphogenesis  
acts_upstream_of mesenchymal cell apoptotic process PubMed 
acts_upstream_of_or_within mesenchymal cell proliferation PubMed 
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development PubMed 
acts_upstream_of_or_within mesenchymal smoothened signaling pathway involved in prostate gland development PubMed 
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development PubMed 
involved_in metanephric collecting duct development  
involved_in metanephric mesenchymal cell proliferation involved in metanephros development PubMed 
involved_in metanephros development PubMed 
acts_upstream_of_or_within midbrain development PubMed 
acts_upstream_of_or_within myoblast differentiation PubMed 
acts_upstream_of_or_within myotube differentiation PubMed 
acts_upstream_of_or_within negative regulation of T cell differentiation in thymus PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of alpha-beta T cell differentiation PubMed 
involved_in negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of cell migration PubMed 
involved_in negative regulation of cholesterol efflux PubMed 
involved_in negative regulation of dopaminergic neuron differentiation PubMed 
involved_in negative regulation of gene expression PubMed 
involved_in negative regulation of kidney smooth muscle cell differentiation PubMed 
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
acts_upstream_of_or_within negative regulation of protein binding PubMed 
acts_upstream_of_or_within negative regulation of protein catabolic process PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II PubMed 
involved_in negative regulation of ureter smooth muscle cell differentiation PubMed 
involved_in negative thymic T cell selection PubMed 
acts_upstream_of_or_within neural crest cell migration PubMed 
involved_in neural tube formation  
acts_upstream_of neuroblast proliferation PubMed 
acts_upstream_of_or_within neuroblast proliferation PubMed 
acts_upstream_of neuroblast proliferation PubMed 
acts_upstream_of neuron differentiation PubMed 
acts_upstream_of neuron differentiation PubMed 
acts_upstream_of_or_within neuron fate commitment PubMed 
acts_upstream_of_or_within odontogenesis PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
acts_upstream_of_or_within oligodendrocyte development PubMed 
involved_in oligodendrocyte differentiation  
acts_upstream_of_or_within oligodendrocyte differentiation PubMed 
acts_upstream_of_or_within osteoblast development PubMed 
acts_upstream_of_or_within pancreas development PubMed 
acts_upstream_of_or_within pancreas development PubMed 
acts_upstream_of_or_within pattern specification process PubMed 
acts_upstream_of_or_within pattern specification process PubMed 
involved_in polarity specification of anterior/posterior axis PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of T cell differentiation in thymus PubMed 
acts_upstream_of_or_within positive regulation of Wnt signaling pathway PubMed 
involved_in positive regulation of alpha-beta T cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of astrocyte differentiation PubMed 
involved_in positive regulation of cell division  
involved_in positive regulation of cell division  
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
involved_in positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation PubMed 
involved_in positive regulation of endothelial cell chemotaxis  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development PubMed 
acts_upstream_of_or_within positive regulation of gene expression PubMed 
involved_in positive regulation of gene expression PubMed 
involved_in positive regulation of immature T cell proliferation in thymus PubMed 
involved_in positive regulation of kidney smooth muscle cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation PubMed 
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
acts_upstream_of_or_within positive regulation of neuroblast proliferation PubMed 
involved_in positive regulation of neuroblast proliferation  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of neurotrophin production  
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation PubMed 
involved_in positive regulation of oligodendrocyte progenitor proliferation  
involved_in positive regulation of penile erection  
involved_in positive regulation of photoreceptor cell differentiation  
acts_upstream_of_or_within positive regulation of protein import into nucleus PubMed 
involved_in positive regulation of sclerotome development  
involved_in positive regulation of sclerotome development  
acts_upstream_of_or_within positive regulation of skeletal muscle cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development PubMed 
involved_in positive regulation of smoothened signaling pathway  
involved_in positive regulation of smoothened signaling pathway  
involved_in positive regulation of sprouting angiogenesis  
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of ureter smooth muscle cell differentiation PubMed 
involved_in positive thymic T cell selection PubMed 
acts_upstream_of_or_within primary prostatic bud elongation PubMed 
acts_upstream_of_or_within prostate epithelial cord elongation PubMed 
acts_upstream_of_or_within prostate gland development PubMed 
NOT acts_upstream_of_or_within prostatic bud formation PubMed 
involved_in protein autoprocessing  
acts_upstream_of protein import into nucleus PubMed 
acts_upstream_of_or_within protein localization to nucleus PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
involved_in regulation of cell population proliferation  
acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development PubMed 
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of gene expression PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
acts_upstream_of_or_within regulation of gene expression PubMed 
acts_upstream_of_or_within regulation of glial cell proliferation PubMed 
acts_upstream_of_or_within regulation of mesenchymal cell proliferation involved in prostate gland development PubMed 
involved_in regulation of odontogenesis PubMed 
acts_upstream_of_or_within regulation of prostatic bud formation PubMed 
acts_upstream_of_or_within regulation of prostatic bud formation PubMed 
involved_in regulation of protein localization to nucleus  
acts_upstream_of_or_within regulation of proteolysis PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation PubMed 
acts_upstream_of_or_within respiratory tube development PubMed 
involved_in response to axon injury  
involved_in response to ethanol  
acts_upstream_of_or_within right lung development PubMed 
acts_upstream_of_or_within roof of mouth development PubMed 
acts_upstream_of_or_within salivary gland cavitation PubMed 
involved_in self proteolysis PubMed 
acts_upstream_of_or_within signal transduction PubMed 
acts_upstream_of skeletal muscle cell proliferation PubMed 
acts_upstream_of_or_within skeletal muscle fiber differentiation PubMed 
acts_upstream_of skeletal muscle tissue development PubMed 
acts_upstream_of_or_within skin development PubMed 
involved_in smooth muscle tissue development  
involved_in smoothened signaling pathway  
acts_upstream_of_or_within smoothened signaling pathway PubMed 
acts_upstream_of_or_within smoothened signaling pathway PubMed 
acts_upstream_of_or_within smoothened signaling pathway PubMed 
involved_in smoothened signaling pathway PubMed 
involved_in smoothened signaling pathway  
involved_in somite development PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning PubMed 
acts_upstream_of_or_within spinal cord dorsal/ventral patterning  
acts_upstream_of_or_within spinal cord motor neuron differentiation PubMed 
involved_in stem cell development PubMed 
acts_upstream_of_or_within stem cell proliferation PubMed 
acts_upstream_of_or_within striated muscle cell differentiation PubMed 
acts_upstream_of_or_within striated muscle tissue development PubMed 
acts_upstream_of_or_within telencephalon regionalization PubMed 
involved_in telencephalon regionalization  
acts_upstream_of_or_within thalamus development PubMed 
acts_upstream_of_or_within thalamus development PubMed 
involved_in thymus development PubMed 
acts_upstream_of_or_within thyroid gland development PubMed 
involved_in tongue development  
involved_in tongue morphogenesis  
acts_upstream_of_or_within trachea development PubMed 
acts_upstream_of_or_within trachea morphogenesis PubMed 
acts_upstream_of_or_within tracheoesophageal septum formation PubMed 
acts_upstream_of trunk neural crest cell migration PubMed 
acts_upstream_of_or_within vasculature development PubMed 
acts_upstream_of_or_within vasculogenesis PubMed 
involved_in vasculogenesis involved in coronary vascular morphogenesis PubMed 
acts_upstream_of_or_within ventral spinal cord interneuron specification  
involved_in zona limitans intrathalamica formation  
Items 1 - 25 of 294
Items 1 - 20 of 22
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi membrane  
located_in axon  
located_in cell surface PubMed 
located_in dendrite  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum lumen  
located_in endoplasmic reticulum membrane  
located_in extracellular matrix PubMed 
located_in extracellular region  
located_in extracellular region  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in membrane PubMed 
located_in membrane raft PubMed 
located_in neuronal cell body  
located_in nucleoplasm  
located_in plasma membrane  
located_in synaptic vesicle  
Items 1 - 20 of 22

General protein information

Preferred Names
sonic hedgehog protein
Names
hemimelic extra toes
shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
short digits

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429000.1NP_001415929.1  sonic hedgehog protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134530
  2. NM_009170.4NP_033196.1  sonic hedgehog protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_033196.1

    Status: VALIDATED

    Source sequence(s)
    AC134530
    Consensus CDS
    CCDS19146.1
    UniProtKB/Swiss-Prot
    Q62226
    UniProtKB/TrEMBL
    Q8C765
    Related
    ENSMUSP00000002708.4, ENSMUST00000002708.5
    Conserved Domains (3) summary
    cd00081
    Location:199349
    Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    pfam01079
    Location:188423
    Hint; Hint module
    pfam01085
    Location:40185
    HH_signal; Hedgehog amino-terminal signalling domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    28661838..28672099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535649.5XP_006535712.1  sonic hedgehog protein isoform X2

    Conserved Domains (2) summary
    pfam01079
    Location:74309
    Hint; Hint module
    pfam01085
    Location:171
    HH_signal; Hedgehog amino-terminal signalling domain
  2. XM_006535648.4XP_006535711.1  sonic hedgehog protein isoform X1

    Conserved Domains (2) summary
    pfam01079
    Location:97332
    Hint; Hint module
    pfam01085
    Location:1094
    HH_signal; Hedgehog amino-terminal signalling domain
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