U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Son Son DNA binding protein [ Mus musculus (house mouse) ]

Gene ID: 20658, updated on 30-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Sonprovided by MGI
Official Full Name
Son DNA binding proteinprovided by MGI
Primary source
MGI:MGI:98353
See related
Ensembl:ENSMUSG00000022961 AllianceGenome:MGI:98353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nrebp; mKIAA1019; 2900011L12Rik
Summary
Enables RS domain binding activity. Predicted to be involved in several processes, including mRNA processing; mitotic cytokinesis; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing. Predicted to be located in nuclear speck. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human SON (SON DNA and RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 48.2), ovary adult (RPKM 44.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Son in Genome Data Viewer
Location:
16 C3.3- C4; 16 53.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91444712..91476080)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91647824..91679192)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene DnaJ heat shock protein family (Hsp40) member C28 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene downstream neighbor of SON Neighboring gene STARR-positive B cell enhancer ABC_E2468 Neighboring gene predicted gene 10785 Neighboring gene crystallin zeta like 1 Neighboring gene predicted gene, 46543

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities. Ueda M, et al. Mol Brain, 2020 May 24. PMID 32448361, Free PMC Article
  2. Conserved gene sequences for species identification: PCR analysis of the 3' UTR of the SON gene distinguishes human and other mammalian DNAs. Soteriou B, et al. Forensic Sci Int, 1995 Jun 21. PMID 7657183
  3. Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. Komori T, et al. J Biol Chem, 2010 Nov 26. PMID 20876580, Free PMC Article
  4. Organization and conservation of the GART/SON/DONSON locus in mouse and human genomes. Wynn SL, et al. Genomics, 2000 Aug 15. PMID 10950926
  5. Disruption of the NHR4 domain structure in AML1-ETO abrogates SON binding and promotes leukemogenesis. Ahn EY, et al. Proc Natl Acad Sci U S A, 2008 Nov 4. PMID 18952841, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.
    Title: A mouse model of Zhu-Tokita-Takenouchi-Kim syndrome reveals indispensable SON functions in organ development and hematopoiesis.
  2. SON is an essential m[6]A target for hematopoietic stem cell fate.
    Title: SON is an essential m(6)A target for hematopoietic stem cell fate.
  3. Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
    Title: Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
  4. SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster
    Title: SON protein regulates GATA-2 through transcriptional control of the microRNA 23a~27a~24-2 cluster.
  5. Leptin-induced NREBP is an important regulator of ghrelin signaling in the hypothalamus.
    Title: Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RS domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein SON
Names
NRE-binding protein
Son cell proliferation protein
negative regulatory element-binding protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019973.2 → NP_064357.2  protein SON isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC131691, AK040621, BC061113, BG229132, CJ088081
    Consensus CDS
    CCDS37400.1
    UniProtKB/TrEMBL
    H9KV01
    Related
    ENSMUSP00000109670.3, ENSMUST00000114036.9
    Conserved Domains (1) summary
    pfam08430
    Location:1011 → 1137
    Forkhead_N; Forkhead N-terminal region

  2. NM_178880.4 → NP_849211.3  protein SON isoform 1

    See identical proteins and their annotated locations for NP_849211.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131691, AK040621, AK122418, BC061113, CB849818, CJ088081
    Consensus CDS
    CCDS37399.1
    UniProtKB/Swiss-Prot
    E3WC91, E9PXW2, E9Q3H8, E9Q3I0, E9Q6M4, E9Q7G2, E9QAR8, E9QMT0, Q811G3, Q9CQ12, Q9CQK6, Q9QX47, Q9QXP5
    UniProtKB/TrEMBL
    H9KV00
    Related
    ENSMUSP00000109671.3, ENSMUST00000114037.9
    Conserved Domains (3) summary
    cd00048
    Location:2389 → 2426
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam08430
    Location:1011 → 1137
    Forkhead_N; Forkhead N-terminal region
    pfam01585
    Location:2323 → 2366
    G-patch; G-patch domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91444712..91476080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QX47.2 GenPept UniProtKB/Swiss-Prot:Q9QX47

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous