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Dnah8 dynein, axonemal, heavy chain 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 207117, updated on 25-Apr-2024

Summary

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Symbol
Dnah8provided by RGD
Full Name
dynein, axonemal, heavy chain 8provided by RGD
Primary source
RGD:619986
See related
Ensembl:ENSRNOG00000000542 AllianceGenome:RGD:619986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dlp8; Dnahc8
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in microtubule-based movement and outer dynein arm assembly. Predicted to be located in axoneme and sperm principal piece. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 127.9) See more
Orthologs
human mouse all
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Genomic context

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See Dnah8 in Genome Data Viewer
Location:
20p12
Exon count:
95
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (8694371..8948849)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (8692939..8946780)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9301317..9560805)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548069 Neighboring gene glyoxalase 1 Neighboring gene uncharacterized LOC134483877 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene uncharacterized LOC120098982 Neighboring gene uncharacterized LOC120098983 Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 3, subunit I, pseudogene 4 Neighboring gene uncharacterized LOC134483876 Neighboring gene glucagon-like peptide 1 receptor Neighboring gene uromodulin-like 1 Neighboring gene uncharacterized LOC134483780

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ATP-driven remodeling of the linker domain in the dynein motor. Roberts AJ, et al. Structure, 2012 Oct 10. PMID 22863569, Free PMC Article
  2. The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail. Samant SA, et al. Dev Biol, 2005 Sep 1. PMID 16054618
  3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
  4. Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Whitfield M, et al. Am J Hum Genet, 2019 Jul 3. PMID 31178125, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity ISO
Inferred from Sequence Orthology
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 8
Names
Atpase
dynein heavy chain 8, axonemal
dynein heavy chain 8, axonemal-like
dynein, axon, heavy chain 8
dynein, axonemal, heavy polypeptide 8
dynein-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427092.1 → NP_001414021.1  dynein axonemal heavy chain 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    F1MAM6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    8694371..8948849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099327.2 → XP_038955255.1  dynein axonemal heavy chain 8 isoform X1

    UniProtKB/TrEMBL
    F1MAM6
    Conserved Domains (4) summary
    COG5245
    Location:1328 → 4375
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:376 → 930
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:2045 → 2372
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4429 → 4724
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_039099333.2 → XP_038955261.1  dynein axonemal heavy chain 8 isoform X2

    Conserved Domains (7) summary
    COG5245
    Location:1328 → 4334
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:376 → 930
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1505 → 1910
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:2045 → 2372
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2986 → 3248
    AAA_8; P-loop containing dynein motor region D4
    pfam12781
    Location:3636 → 3853
    AAA_9; ATP-binding dynein motor region D5
    pfam18199
    Location:4388 → 4683
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_039099329.2 → XP_038955257.1  dynein axonemal heavy chain 8 isoform X1

    UniProtKB/TrEMBL
    F1MAM6
    Conserved Domains (4) summary
    COG5245
    Location:1328 → 4375
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:376 → 930
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:2045 → 2372
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4429 → 4724
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_039099330.2 → XP_038955258.1  dynein axonemal heavy chain 8 isoform X1

    UniProtKB/TrEMBL
    F1MAM6
    Conserved Domains (4) summary
    COG5245
    Location:1328 → 4375
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:376 → 930
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:2045 → 2372
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4429 → 4724
    Dynein_C; Dynein heavy chain C-terminal domain

  5. XM_039099328.2 → XP_038955256.1  dynein axonemal heavy chain 8 isoform X1

    UniProtKB/TrEMBL
    F1MAM6
    Conserved Domains (4) summary
    COG5245
    Location:1328 → 4375
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:376 → 930
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam12774
    Location:2045 → 2372
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam18199
    Location:4429 → 4724
    Dynein_C; Dynein heavy chain C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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