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Diras1 DIRAS family, GTP-binding RAS-like 1 [ Mus musculus (house mouse) ]

Gene ID: 208666, updated on 5-Mar-2024

Summary

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Official Symbol
Diras1provided by MGI
Official Full Name
DIRAS family, GTP-binding RAS-like 1provided by MGI
Primary source
MGI:MGI:2183442
See related
Ensembl:ENSMUSG00000043670 AllianceGenome:MGI:2183442
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RIG; Gbts1; Di-Ras1
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; olfactory epithelium; peripheral nervous system ganglion; and retina. Orthologous to human DIRAS1 (DIRAS family GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 26.6), cortex adult (RPKM 16.0) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Diras1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80855423..80862038, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81019589..81025835, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E721 Neighboring gene growth arrest and DNA-damage-inducible 45 beta Neighboring gene STARR-seq mESC enhancer starr_27304 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene STARR-seq mESC enhancer starr_27308 Neighboring gene guanine nucleotide binding protein (G protein), gamma 7 Neighboring gene STARR-seq mESC enhancer starr_27310 Neighboring gene STARR-positive B cell enhancer ABC_E2951 Neighboring gene STARR-positive B cell enhancer ABC_E1807 Neighboring gene STARR-positive B cell enhancer ABC_E10629 Neighboring gene predicted gene 16099 Neighboring gene STARR-positive B cell enhancer ABC_E2952 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1808 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Fritsch R, et al. Cell, 2013 May 23. PMID 23706742, Free PMC Article
  2. Y chromosomal noncoding RNAs regulate autosomal gene expression via piRNAs in mouse testis. Reddy HM, et al. BMC Biol, 2021 Sep 9. PMID 34503492, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GTP-binding protein Di-Ras1
Names
distinct subgroup of the Ras family member 1
small GTP-binding tumor suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145217.2 → NP_660252.1  GTP-binding protein Di-Ras1

    See identical proteins and their annotated locations for NP_660252.1

    Status: PROVISIONAL

    Source sequence(s)
    BC057556
    Consensus CDS
    CCDS24040.1
    UniProtKB/Swiss-Prot
    Q91Z61
    Related
    ENSMUSP00000055605.5, ENSMUST00000055125.5
    Conserved Domains (1) summary
    cl38936
    Location:7 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80855423..80862038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513438.5 → XP_006513501.1  GTP-binding protein Di-Ras1 isoform X1

    See identical proteins and their annotated locations for XP_006513501.1

    UniProtKB/Swiss-Prot
    Q91Z61
    Conserved Domains (1) summary
    cl38936
    Location:7 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z61.1 GenPept UniProtKB/Swiss-Prot:Q91Z61

Gene LinkOut

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