Wwc1 WW, C2 and coiled-coil domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wwc1provided by MGI
Official Full Name: WW, C2 and coiled-coil domain containing 1provided by MGI
Primary source: MGI:MGI:2388637
See related: Ensembl:ENSMUSG00000018849 AllianceGenome:MGI:2388637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kibra
Summary: Predicted to enable kinase binding activity; protein-macromolecule adaptor activity; and transcription coactivator activity. Predicted to be involved in several processes, including negative regulation of organ growth; negative regulation of transcription by RNA polymerase II; and regulation of intracellular signal transduction. Located in cytoplasm. Is expressed in female associated reproductive structure; ureteric tip; and ureteric trunk. Orthologous to human WWC1 (WW and C2 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 52.0), kidney adult (RPKM 44.9) and 22 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11 A4; 11 21.96 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (35729226..35871354, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (35838399..35980527, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Title: Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathway.
Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism.
Title: Experience alters hippocampal and cortical network communication via a KIBRA-dependent mechanism.
KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression.
Title: KIBRA upregulation increases susceptibility to podocyte injury and glomerular disease progression.
KIBRA regulates amyloid beta metabolism by controlling extracellular vesicles secretion.
Title: KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion.
Kibra WW tandem domains bind to dendrin. Disruption of the Kibra/Dendrin interaction impairs learning and memory in mice.
Title: Kibra Modulates Learning and Memory via Binding to Dendrin.
KIBRA inhibited CAMDI-dependent Rab11 activation, thereby attenuating AMPAR cell surface expression.
Title: CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition.
KIBRA functions co-operatively with the protein tyrosine phosphatase PTPN14 to trigger mechanotransduction-regulated signals that inhibit the nuclear localization of oncogenic transcriptional co-activators YAP/TAZ. Our results argue that the selective advantage produced by 5q loss involves reduced dosage of KIBRA, promoting oncogenic functioning of YAP/TAZ in TNBC.
Title: KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer.
Comparing protein profiles between KIBRA knockout and wild-type mouse brain showed significantly decreased Rab27a. Rab27a is stabilized by interacting with KIBRA, which prevents ubiquitination and degradation via the ubiquitin-proteasome pathway.
Title: KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a.
Study illustrated the expression at the protein level of a memory-related protein-KIBRA in the intestine of APP/PS1 Alzheimer disease mouse model. Protein levels of KIBRA significantly increased in the jejunal myenteric plexus of APP/PS1 mice.
Title: Unique expression pattern of KIBRA in the enteric nervous system of APP/PS1 mice.
study provides a mechanistic link between aberrant tau acetylation, KIBRA deficiency, and dementia in Alzheimer's disease
Title: Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH141360 (e-PCR)
- UniSTS:223356

AU049672 (e-PCR)
- UniSTS:146118

AU017197 (e-PCR)
- UniSTS:180176

RH125783 (e-PCR)
- UniSTS:162530

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of hippo signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein KIBRA

Names: WW domain-containing protein 1; kidney and brain protein; protein WWC1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170779.2 → NP_740749.1 protein KIBRA

See identical proteins and their annotated locations for NP_740749.1

Status: VALIDATED

Source sequence(s)

AL596084, AL645912

Consensus CDS

CCDS24545.1

UniProtKB/Swiss-Prot

Q571D0, Q5SXA9, Q8K1Y3, Q8VD17, Q922W3

UniProtKB/TrEMBL

Q0KIX1

Related

ENSMUSP00000018993.7, ENSMUST00000018993.7

Conserved Domains (4) summary

cd08680
Location:661 → 784

C2_Kibra; C2 domain found in Human protein Kibra

cd00201
Location:9 → 39

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:55 → 84

WW; WW domain

cl11961
Location:378 → 420

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

35729226..35871354 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245754.1 → XP_030101614.1 protein KIBRA isoform X1

UniProtKB/TrEMBL

Q0KIX1

Conserved Domains (3) summary

cd08680
Location:567 → 690

C2_Kibra; C2 domain found in Human protein Kibra

COG1196
Location:60 → 317

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04211
Location:201 → 328

SH3_and_anchor; SH3 domain protein