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Tcp11 t-complex protein 11 [ Mus musculus (house mouse) ]

Gene ID: 21463, updated on 14-May-2024

Summary

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Official Symbol
Tcp11provided by MGI
Official Full Name
t-complex protein 11provided by MGI
Primary source
MGI:MGI:98544
See related
Ensembl:ENSMUSG00000062859 AllianceGenome:MGI:98544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcp-11; D17Ken1
Summary
Involved in several processes, including protein kinase A signaling; regulation of cAMP-mediated signaling; and regulation of sperm capacitation. Located in acrosomal vesicle and sperm midpiece. Is expressed in testis. Orthologous to human TCP11 (t-complex 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 841.9) See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.62 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28285725..28299583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28066747..28080726, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7504 Neighboring gene TATA-box binding protein associated factor 11 Neighboring gene ankyrin repeat and SAM domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42177 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28144121-28144327 Neighboring gene predicted gene, 35290 Neighboring gene tRNA splicing endonuclease 34 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42185 Neighboring gene STARR-positive B cell enhancer ABC_E4199 Neighboring gene VISTA enhancer mm1525 Neighboring gene signal peptide, CUB domain, EGF-like 3 Neighboring gene zinc finger protein 523

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse t-complex protein 11 is important for progressive motility in sperm†. Castaneda JM, et al. Biol Reprod, 2020 Apr 15. PMID 31837139, Free PMC Article
  2. The modulation of sperm function by fertilization promoting peptide. Fraser LR. Hum Reprod, 1998 Dec. PMID 10091053
  3. The mouse t-complex gene, Tcp-11, is under translational control. Hosseini R, et al. Mech Dev, 1994 Jul. PMID 7947323
  4. FPP modulates mammalian sperm function via TCP-11 and the adenylyl cyclase/cAMP pathway. Adeoya-Osiguwa SA, et al. Mol Reprod Dev, 1998 Dec. PMID 9820206
  5. Isolation and characterisation of a testis-expressed developmentally regulated gene from the distal inversion of the mouse t-complex. Mazarakis ND, et al. Development, 1991 Feb. PMID 1893875

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse t-complex protein 11 is important for progressive motility in spermdagger.
    Title: Mouse t-complex protein 11 is important for progressive motility in sperm†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

General gene information

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Homology

Clone Names

  • MGC107229

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein kinase A signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of sperm capacitation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
T-complex protein 11
Names
testis-specific protein PBS13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085555.2 → NP_001079024.1  T-complex protein 11 isoform 2

    See identical proteins and their annotated locations for NP_001079024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC132460
    Consensus CDS
    CCDS50045.1
    UniProtKB/TrEMBL
    Q01756, Q5FWA2
    Related
    ENSMUSP00000046002.9, ENSMUST00000043925.16
    Conserved Domains (1) summary
    pfam05794
    Location:67 → 472
    Tcp11; T-complex protein 11

  2. NM_001357681.2 → NP_001344610.1  T-complex protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132460
    Consensus CDS
    CCDS50045.1
    UniProtKB/TrEMBL
    Q01756, Q5FWA2
    Related
    ENSMUSP00000110485.2, ENSMUST00000114836.9
    Conserved Domains (1) summary
    pfam05794
    Location:67 → 472
    Tcp11; T-complex protein 11

  3. NM_001374620.1 → NP_001361549.1  T-complex protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    A0A3B2W7H0, Q01756
    Related
    ENSMUSP00000156512.2, ENSMUST00000233898.2
    Conserved Domains (1) summary
    pfam05794
    Location:33 → 438
    Tcp11; T-complex protein 11

  4. NM_001374621.1 → NP_001361550.1  T-complex protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    A0A3B2WD68, Q01756
    Related
    ENSMUSP00000156874.2, ENSMUST00000232798.2
    Conserved Domains (1) summary
    pfam05794
    Location:26 → 431
    Tcp11; T-complex protein 11

  5. NM_001399994.1 → NP_001386923.1  T-complex protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    B2KF24, B2KF25

  6. NM_001399995.1 → NP_001386924.1  T-complex protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    B2KF24, B2KF25

  7. NM_001399996.1 → NP_001386925.1  T-complex protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    Q5FWA2

  8. NM_001399998.1 → NP_001386927.1  T-complex protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    Q5FWA2

  9. NM_001399999.1 → NP_001386928.1  T-complex protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132460
    UniProtKB/TrEMBL
    A0A3B2WD68
    Related
    ENSMUST00000233961.2

  10. NM_001400000.1 → NP_001386929.1  T-complex protein 11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132460

  11. NM_013687.4 → NP_038715.2  T-complex protein 11 isoform 1

    See identical proteins and their annotated locations for NP_038715.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132460
    Consensus CDS
    CCDS37526.1
    UniProtKB/Swiss-Prot
    Q01755
    UniProtKB/TrEMBL
    B2KF24, B2KF25
    Related
    ENSMUSP00000038590.6, ENSMUST00000042692.13
    Conserved Domains (1) summary
    pfam05794
    Location:146 → 548
    Tcp11; T-complex protein 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28285725..28299583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01755.1 GenPept UniProtKB/Swiss-Prot:Q01755

Gene LinkOut

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