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F2R coagulation factor II thrombin receptor [ Homo sapiens (human) ]

Gene ID: 2149, updated on 4-Jan-2025

Summary

Official Symbol
F2Rprovided by HGNC
Official Full Name
coagulation factor II thrombin receptorprovided by HGNC
Primary source
HGNC:HGNC:3537
See related
Ensembl:ENSG00000181104 MIM:187930; AllianceGenome:HGNC:3537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR; HTR; CF2R; PAR1; PAR-1
Summary
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in spleen (RPKM 37.1), gall bladder (RPKM 26.8) and 21 other tissues See more
Orthologs
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Genomic context

See F2R in Genome Data Viewer
Location:
5q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (76716126..76735770)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77198009..77217657)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76011951..76031595)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene Sharpr-MPRA regulatory region 1022 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76013800-76014300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76014301-76014801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22697 Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76068685-76069184 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:76074968-76075586 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76094678-76095178 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:76099560-76100759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76101363-76101946 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76101947-76102528 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76103693-76104276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76110384-76111038 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:76114571-76115188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76115189-76115806 Neighboring gene F2R like trypsin receptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
New gene functions in megakaryopoiesis and platelet formation.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infectivity is decreased by F2R (PAR1), but not F2R (PAR1) mutant R46A, overexpression in the virus producing cells (HEK293T) PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 (HXBC2) gp160 furin-mediated processing is inhibited by F2R (PAR1) whilst F2R (PAR1) K46A does not (in COS-1 and HEK293T cells), indicating amino acid residue F2R Arg46 as critical for the inhibitory effect PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp160 furin-mediated processing to gp41 is inhibited by PAR1 in cells (COS-1 and HEK293T) overexpressing F2R PubMed
Vpr vpr F2R (PAR1) DOES NOT block processing of Vpr by soluble PCSK6 (PACE4) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity  
enables G protein-coupled receptor activity PubMed 
enables G-protein alpha-subunit binding  
enables G-protein beta-subunit binding  
enables protein binding PubMed 
enables signaling receptor binding PubMed 
enables thrombin-activated receptor activity  
enables thrombin-activated receptor activity PubMed 
Items 1 - 25 of 47
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in anatomical structure morphogenesis PubMed 
involved_in cell-cell junction maintenance PubMed 
involved_in connective tissue replacement involved in inflammatory response wound healing PubMed 
involved_in dendritic cell homeostasis  
involved_in establishment of synaptic specificity at neuromuscular junction  
involved_in homeostasis of number of cells within a tissue  
involved_in inflammatory response  
involved_in negative regulation of cell population proliferation PubMed 
involved_in negative regulation of glomerular filtration  
involved_in negative regulation of neuron apoptotic process  
involved_in negative regulation of renin secretion into blood stream  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway  
involved_in platelet activation PubMed 
involved_in platelet dense granule organization PubMed 
involved_in positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of GTPase activity PubMed 
involved_in positive regulation of MAPK cascade PubMed 
involved_in positive regulation of Rho protein signal transduction  
involved_in positive regulation of apoptotic process PubMed 
involved_in positive regulation of blood coagulation  
involved_in positive regulation of blood coagulation PubMed 
involved_in positive regulation of calcium ion transport  
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of cell migration PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of collagen biosynthetic process PubMed 
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of interleukin-6 production PubMed 
involved_in positive regulation of interleukin-8 production PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of receptor signaling pathway via JAK-STAT PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol PubMed 
involved_in positive regulation of smooth muscle contraction  
involved_in positive regulation of vasoconstriction  
involved_in regulation of blood coagulation PubMed 
involved_in regulation of interleukin-1 beta production  
involved_in regulation of sensory perception of pain  
involved_in regulation of synaptic plasticity  
involved_in release of sequestered calcium ion into cytosol  
involved_in response to lipopolysaccharide  
involved_in response to wounding PubMed 
involved_in thrombin-activated receptor signaling pathway PubMed 
involved_in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  
Items 1 - 25 of 47
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in caveola PubMed 
located_in cell surface PubMed 
located_in early endosome PubMed 
located_in extracellular region  
located_in late endosome PubMed 
located_in neuromuscular junction  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
is_active_in plasma membrane  
located_in plasma membrane  
located_in platelet dense tubular network PubMed 
located_in postsynaptic membrane  

General protein information

Preferred Names
proteinase-activated receptor 1
Names
protease-activated receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032906.1 RefSeqGene

    Range
    5084..24728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_641

mRNA and Protein(s)

  1. NM_001311313.2NP_001298242.1  proteinase-activated receptor 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK308169, BC051909, BM994328, DA799420
    UniProtKB/TrEMBL
    B4DLS3
    Conserved Domains (2) summary
    cd14964
    Location:1738
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1261
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001992.5NP_001983.2  proteinase-activated receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001983.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC051909, BM994328
    Consensus CDS
    CCDS4032.1
    UniProtKB/Swiss-Prot
    P25116, Q53XV0, Q96RF7, Q9BUN4
    Related
    ENSP00000321326.4, ENST00000319211.5
    Conserved Domains (1) summary
    pfam00001
    Location:120371
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    76716126..76735770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    77198009..77217657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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