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Cdc34 cell division cycle 34 [ Mus musculus (house mouse) ]

Gene ID: 216150, updated on 12-May-2024

Summary

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Official Symbol
Cdc34provided by MGI
Official Full Name
cell division cycle 34provided by MGI
Primary source
MGI:MGI:102657
See related
Ensembl:ENSMUSG00000020307 AllianceGenome:MGI:102657
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UBE2R1; E2-CDC34
Summary
Enables ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular protein metabolic process; cellular response to interferon-beta; and negative regulation of cAMP-mediated signaling. Predicted to be located in cytosol and nuclear speck. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 167.9), placenta adult (RPKM 79.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79518029..79524232)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79682193..79688398)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E8346 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3896 Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene predicted gene, 25794

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reprogrammable recognition codes in bicoid homeodomain-DNA interaction. Dave V, et al. Mol Cell Biol, 2000 Oct. PMID 11003663, Free PMC Article
  2. Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover Formation with Cell-Cycle Progression in a Cyclin-Independent Manner. Gray S, et al. Cell Rep, 2020 Jul 7. PMID 32640224, Free PMC Article
  3. Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Campbell PK, et al. Genetics, 2002 Sep. PMID 12242242, Free PMC Article
  4. Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast. Plon SE, et al. Proc Natl Acad Sci U S A, 1993 Nov 15. PMID 8248134, Free PMC Article
  5. Differential ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities. Choi YS, et al. J Biol Chem, 2015 Jan 23. PMID 25471371, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 R1
Names
(E3-independent) E2 ubiquitin-conjugating enzyme R1
E2 ubiquitin-conjugating enzyme R1
cell division cycle 34 homolog
ubiquitin-conjugating enzyme Cdc34
ubiquitin-conjugating enzyme E2-32 kDa complementing
ubiquitin-conjugating enzyme E2-CDC34
ubiquitin-protein ligase R1
NP_001346746.1
NP_001346747.1
NP_808281.1
XP_017169376.1
XP_017169377.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359817.1 → NP_001346746.1  ubiquitin-conjugating enzyme E2 R1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC151828, BE988402, BY083281, BY114161, CA320111
    Consensus CDS
    CCDS88049.1
    UniProtKB/TrEMBL
    A0A1W2P7U1
    Related
    ENSMUSP00000151763.2, ENSMUST00000219791.2
    Conserved Domains (1) summary
    cd00195
    Location:11 → 125
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001359818.1 → NP_001346747.1  ubiquitin-conjugating enzyme E2 R1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC151828, BE988402, BY114161, CA320111, CX210748
    UniProtKB/TrEMBL
    A0A1W2P7U9
    Related
    ENSMUSP00000152000.2, ENSMUST00000218964.2
    Conserved Domains (1) summary
    cd00195
    Location:11 → 162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_177613.2 → NP_808281.1  ubiquitin-conjugating enzyme E2 R1 isoform 1

    See identical proteins and their annotated locations for NP_808281.1

    Status: VALIDATED

    Source sequence(s)
    BC039160
    Consensus CDS
    CCDS23983.1
    UniProtKB/Swiss-Prot
    Q505K8, Q8CFI2
    UniProtKB/TrEMBL
    A0A087WP01
    Related
    ENSMUSP00000020550.6, ENSMUST00000020550.13
    Conserved Domains (1) summary
    cd00195
    Location:11 → 162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    79518029..79524232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313888.3 → XP_017169377.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

    UniProtKB/Swiss-Prot
    Q505K8, Q8CFI2
    UniProtKB/TrEMBL
    A0A087WP01
    Conserved Domains (1) summary
    cd00195
    Location:11 → 162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. XM_017313887.2 → XP_017169376.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

    UniProtKB/Swiss-Prot
    Q505K8, Q8CFI2
    UniProtKB/TrEMBL
    A0A087WP01
    Conserved Domains (1) summary
    cd00195
    Location:11 → 162
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFI2.1 GenPept UniProtKB/Swiss-Prot:Q8CFI2

Gene LinkOut

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