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FAAH fatty acid amide hydrolase [ Homo sapiens (human) ]

Gene ID: 2166, updated on 4-Jan-2025

Summary

Official Symbol
FAAHprovided by HGNC
Official Full Name
fatty acid amide hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:3553
See related
Ensembl:ENSG00000117480 MIM:602935; AllianceGenome:HGNC:3553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSAB; FAAH1; FAAH-1
Summary
This gene encodes a protein that is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide. [provided by RefSeq, Jul 2008]
Expression
Broad expression in prostate (RPKM 30.1), thyroid (RPKM 21.8) and 23 other tissues See more
Orthologs
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Genomic context

See FAAH in Genome Data Viewer
Location:
1p33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46394317..46413845)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46271530..46291059)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (46859989..46879517)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46768959-46769542 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46769543-46770124 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46794429-46795157 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:46795158-46795887 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46795888-46796616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46797347-46798076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 845 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:46804880-46805679 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1000 Neighboring gene NOP2/Sun RNA methyltransferase 4 Neighboring gene MPRA-validated peak205 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:46837735-46837899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46859877-46860390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1001 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:46898417-46899137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1003 Neighboring gene fatty acid amide hydrolase pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46913491-46914002 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:46914003-46914516 Neighboring gene long intergenic non-protein coding RNA 1398

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Polysubstance abuse, susceptibility to
MedGen: C1847831 OMIM: 606581 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC102823, MGC138146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amidase activity  
enables fatty acid amide hydrolase activity  
enables fatty acid amide hydrolase activity PubMed 
enables fatty acid amide hydrolase activity  
enables fatty acid amide hydrolase activity  
enables identical protein binding  
enables monoacylglycerol lipase activity  
enables phospholipid binding  
enables protein binding PubMed 
Component Evidence Code Pubs
located_in cytoskeleton  
located_in endoplasmic reticulum membrane  
located_in glutamatergic synapse  
located_in organelle membrane  
located_in postsynapse  
located_in presynapse  

General protein information

Preferred Names
fatty-acid amide hydrolase 1
Names
anandamide amidohydrolase 1
fatty acid ester hydrolase
oleamide hydrolase 1
NP_001432.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012195.2 RefSeqGene

    Range
    5002..24530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001441.3NP_001432.2  fatty-acid amide hydrolase 1

    See identical proteins and their annotated locations for NP_001432.2

    Status: REVIEWED

    Source sequence(s)
    AL122001
    Consensus CDS
    CCDS535.1
    UniProtKB/Swiss-Prot
    D3DQ19, O00519, Q52M86, Q5TDF8
    Related
    ENSP00000243167.8, ENST00000243167.9
    Conserved Domains (1) summary
    pfam01425
    Location:95562
    Amidase; Amidase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    46394317..46413845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    46271530..46291059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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