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Acsl6 acyl-CoA synthetase long-chain family member 6 [ Mus musculus (house mouse) ]

Gene ID: 216739, updated on 14-May-2024

Summary

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Official Symbol
Acsl6provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 6provided by MGI
Primary source
MGI:MGI:894291
See related
Ensembl:ENSMUSG00000020333 AllianceGenome:MGI:894291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LACS; Facl6; Lacsl; mKIAA0837; A330035H04Rik
Summary
Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within neuroblast proliferation. Located in mitochondrion. Is expressed in heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 31.2), cortex adult (RPKM 27.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Acsl6 in Genome Data Viewer
Location:
11 B1.3; 11 32.13 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54194580..54255582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54303805..54364756)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene interleukin 3 Neighboring gene STARR-seq mESC enhancer starr_29507 Neighboring gene predicted gene, 51861 Neighboring gene predicted gene 12224 Neighboring gene meiotic kinetochore factor Neighboring gene mucolipin 2 pseudogene Neighboring gene oxidative stress responsive 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. Fernandez RF, et al. JCI Insight, 2021 Jun 8. PMID 34100386, Free PMC Article
  2. Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes. Jung YH, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Jul. PMID 32126286
  3. Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse. Hale BJ, et al. J Biol Chem, 2019 Sep 27. PMID 31399511, Free PMC Article
  4. Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain. Fernandez RF, et al. Proc Natl Acad Sci U S A, 2018 Dec 4. PMID 30401738, Free PMC Article
  5. Alternative promotion of the mouse acyl-CoA synthetase 6 (mAcsl6) gene mediates the expression of multiple transcripts with 5'-end heterogeneity: genetic organization of mAcsl6 variants. Lee EJ, et al. Biochem Biophys Res Commun, 2005 Feb 4. PMID 15629433

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice.
    Title: Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice.
  2. Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
    Title: Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
  3. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
    Title: Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
  4. Acyl-CoA synthetase 6 regulates DHA and DPA composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice
    Title: Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice.
  5. Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes.
    Title: Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes.
  6. ACSL6 is essential for germ cell DHA enrichment and is required for normal spermatogenesis and male fertility.
    Title: Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse.
  7. Acsl6 knockout mice demonstrate motor impairments, altered glutamate metabolism, and increased astrogliosis and microglia activation.
    Title: Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain.
  8. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
    Title: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
  9. Long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation.
    Title: A novel murine long-chain acyl-CoA synthetase expressed in brain participates in neuronal cell proliferation.
  10. Acsl6 promoter 1 (mAcsl6_pr1) region has a negative regulatory function
    Title: Alternative promotion of the mouse acyl-CoA synthetase 6 (mAcsl6) gene mediates the expression of multiple transcripts with 5'-end heterogeneity: genetic organization of mAcsl6 variants.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36650

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 6
Names
LACS 6
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 6
long-chain acyl-CoA synthetase 6
NP_001028769.1
NP_001028770.1
NP_001028771.1
NP_659072.3
XP_006532906.1
XP_006532907.1
XP_006532908.1
XP_030101661.1
XP_030101662.1
XP_036012431.1
XP_036012432.1
XP_036012433.1
XP_036012434.1
XP_036012435.1
XP_036012436.1
XP_036012437.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033597.1 → NP_001028769.1  long-chain-fatty-acid--CoA ligase 6 isoform 2

    See identical proteins and their annotated locations for NP_001028769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is the same length as but includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region.
    Source sequence(s)
    AL596127, AL603822, BC022959
    Consensus CDS
    CCDS24694.1
    UniProtKB/TrEMBL
    Q5ICG6, Q8R1X1
    Related
    ENSMUSP00000104532.4, ENSMUST00000108904.10
    Conserved Domains (2) summary
    PLN02736
    Location:104 → 718
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:141 → 718
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_001033598.1 → NP_001028770.1  long-chain-fatty-acid--CoA ligase 6 isoform 3

    See identical proteins and their annotated locations for NP_001028770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK147283
    Consensus CDS
    CCDS24696.1
    UniProtKB/Swiss-Prot
    Q80ZF1, Q91WC3
    UniProtKB/TrEMBL
    A8IP90, Q5ICG4
    Related
    ENSMUSP00000090795.6, ENSMUST00000093106.12
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. NM_001033599.1 → NP_001028771.1  long-chain-fatty-acid--CoA ligase 6 isoform 4

    See identical proteins and their annotated locations for NP_001028771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses a downstream start codon, and also includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus and also differs in an internal region, compared to isoform 1.
    Source sequence(s)
    AL596127, AY786362, BB634066
    Consensus CDS
    CCDS24697.1
    UniProtKB/TrEMBL
    A8IP90, Q5ICG5
    Related
    ENSMUSP00000098773.3, ENSMUST00000101213.9
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. NM_144823.4 → NP_659072.3  long-chain-fatty-acid--CoA ligase 6 isoform 1

    See identical proteins and their annotated locations for NP_659072.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AK147421
    Consensus CDS
    CCDS24695.1
    UniProtKB/TrEMBL
    Q5F2D0, Q5ICG6
    Related
    ENSMUSP00000104533.4, ENSMUST00000108905.10
    Conserved Domains (2) summary
    PLN02736
    Location:104 → 718
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:141 → 718
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54194580..54255582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245801.2 → XP_030101661.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

    UniProtKB/TrEMBL
    A8IP90, Q5ICG5
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_036156542.1 → XP_036012435.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

    UniProtKB/TrEMBL
    A8IP90
    Conserved Domains (1) summary
    cd05927
    Location:116 → 667
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  3. XM_030245802.2 → XP_030101662.1  long-chain-fatty-acid--CoA ligase 6 isoform X6

    UniProtKB/TrEMBL
    Q5ICG6
    Conserved Domains (1) summary
    cd05927
    Location:141 → 744
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. XM_036156540.1 → XP_036012433.1  long-chain-fatty-acid--CoA ligase 6 isoform X3

    UniProtKB/TrEMBL
    Q5ICG6
    Conserved Domains (1) summary
    cd05927
    Location:141 → 692
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  5. XM_006532843.2 → XP_006532906.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

    See identical proteins and their annotated locations for XP_006532906.1

    UniProtKB/Swiss-Prot
    Q80ZF1, Q91WC3
    UniProtKB/TrEMBL
    A8IP90, Q5ICG4
    Related
    ENSMUSP00000072040.5, ENSMUST00000072178.11
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  6. XM_036156541.1 → XP_036012434.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

    UniProtKB/TrEMBL
    A8IP90
    Conserved Domains (1) summary
    cd05927
    Location:116 → 667
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  7. XM_036156538.1 → XP_036012431.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

    UniProtKB/Swiss-Prot
    Q80ZF1, Q91WC3
    UniProtKB/TrEMBL
    A8IP90, Q5ICG4
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  8. XM_006532844.1 → XP_006532907.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

    See identical proteins and their annotated locations for XP_006532907.1

    UniProtKB/Swiss-Prot
    Q80ZF1, Q91WC3
    UniProtKB/TrEMBL
    A8IP90, Q5ICG4
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  9. XM_036156543.1 → XP_036012436.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

    UniProtKB/TrEMBL
    A8IP90
    Conserved Domains (1) summary
    cd05927
    Location:116 → 667
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  10. XM_036156539.1 → XP_036012432.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

    UniProtKB/TrEMBL
    A8IP90, Q5ICG5
    Related
    ENSMUSP00000098771.3, ENSMUST00000101211.9
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  11. XM_006532845.3 → XP_006532908.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

    See identical proteins and their annotated locations for XP_006532908.1

    UniProtKB/TrEMBL
    A8IP90, Q5ICG5
    Conserved Domains (1) summary
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  12. XM_036156544.1 → XP_036012437.1  long-chain-fatty-acid--CoA ligase 6 isoform X5

    UniProtKB/TrEMBL
    Q80TQ7
    Conserved Domains (1) summary
    cl17068
    Location:1 → 369
    AFD_class_I; Adenylate forming domain, Class I superfamily

RNA

  1. XR_004936915.1 RNA Sequence

  2. XR_003949381.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WC3.1 GenPept UniProtKB/Swiss-Prot:Q91WC3

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