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Usp22 ubiquitin specific peptidase 22 [ Mus musculus (house mouse) ]

Gene ID: 216825, updated on 12-May-2024

Summary

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Official Symbol
Usp22provided by MGI
Official Full Name
ubiquitin specific peptidase 22provided by MGI
Primary source
MGI:MGI:2144157
See related
Ensembl:ENSMUSG00000042506 AllianceGenome:MGI:2144157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables thiol-dependent deubiquitinase. Acts upstream of or within protein deubiquitination. Predicted to be located in nucleus. Predicted to be part of SAGA complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Orthologous to human USP22 (ubiquitin specific peptidase 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 112.1), whole brain E14.5 (RPKM 101.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.96 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61042607..61065885, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61151781..61175059, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene STARR-positive B cell enhancer ABC_E8878 Neighboring gene STARR-positive B cell enhancer ABC_E5234 Neighboring gene STARR-positive B cell enhancer ABC_E8412 Neighboring gene tumor necrosis factor receptor superfamily, member 13b Neighboring gene STARR-positive B cell enhancer ABC_E3956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60973670-60973823 Neighboring gene STARR-positive B cell enhancer ABC_E374 Neighboring gene STARR-seq mESC enhancer starr_29671 Neighboring gene predicted gene, 42080 Neighboring gene ribosomal protein S13, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Usp22 is an intracellular regulator of systemic emergency hematopoiesis. Dietlein N, et al. Sci Immunol, 2022 Dec 16. PMID 36490327
  2. Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury. Zhang Z, et al. Neuroscience, 2022 Aug 1. PMID 35700816
  3. USP22 promotes pro‑inflammatory responses in Pseudomonas aeruginosa‑induced keratitis by targeting TRAF6. Chen D, et al. Mol Med Rep, 2022 May. PMID 35244191
  4. Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization. Wang Y, et al. Cells Dev, 2021 Jun. PMID 33994359
  5. Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer. Li J, et al. Cancer Immunol Res, 2020 Mar. PMID 31871120, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
    Title: USP22 supports the aggressive behavior of basal-like breast cancer by stimulating cellular respiration.
  2. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway.
    Title: USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway.
  3. Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-alpha-TAK1 signaling pathway.
    Title: Loss of USP22 alleviates cardiac hypertrophy induced by pressure overload through HiF1-α-TAK1 signaling pathway.
  4. USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
    Title: USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
  5. Usp22 is an intracellular regulator of systemic emergency hematopoiesis.
    Title: Usp22 is an intracellular regulator of systemic emergency hematopoiesis.
  6. Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury.
    Title: Ubiquitin-Specific Protease 22 Promotes Neural Stem Cells Stemness Maintenance and Adult Hippocampal Neurogenesis, Contributing to Cognitive Recovery Following Traumatic Brain Injury.
  7. USP22 promotes proinflammatory responses in Pseudomonas aeruginosainduced keratitis by targeting TRAF6.
    Title: USP22 promotes pro‑inflammatory responses in Pseudomonas aeruginosa‑induced keratitis by targeting TRAF6.
  8. USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
    Title: USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
  9. Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization.
    Title: Usp22 is expressed in mouse uterus during early pregnancy and involved in endometrial stromal cell decidualization.
  10. USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
    Title: USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1063, MGC91200

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2A deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H2B deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 22
Names
deubiquitinating enzyme 22
ubiquitin specific protease 22
ubiquitin thioesterase 22
ubiquitin thiolesterase 22
ubiquitin-specific-processing protease 22
NP_001004143.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004143.4 → NP_001004143.2  ubiquitin carboxyl-terminal hydrolase 22

    See identical proteins and their annotated locations for NP_001004143.2

    Status: VALIDATED

    Source sequence(s)
    AK160992, AL646093
    Consensus CDS
    CCDS24807.1
    UniProtKB/Swiss-Prot
    Q3TU34, Q3U2W4, Q5DU02, Q5SU81, Q66JV8, Q6PDX3, Q8BJG3
    Related
    ENSMUSP00000041263.9, ENSMUST00000041683.9
    Conserved Domains (2) summary
    cd02660
    Location:176 → 518
    Peptidase_C19D; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam02148
    Location:63 → 123
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61042607..61065885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU02.2 GenPept UniProtKB/Swiss-Prot:Q5DU02

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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